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DNA Nanotechnology‐Based Supramolecular Assemblies for Targeted Biomedical Applications

DNA Nanotechnology‐Based Supramolecular Assemblies for Targeted Biomedical Applications DNA is a polyanionic, hydrophilic, and natural biopolymer that offers properties such as biodegradability, biocompatibility, non‐toxicity, and non‐immunogenicity. These properties of DNA as an ideal biopolymer offer modern‐day researchers’ reasons to exploit these to form high‐order supramolecular assemblies. These structures could range from simple to complex and provide various applications. Among them, supramolecular assemblies like DNA hydrogels (DNA‐HG) and DNA dendrimers (DNA‐DS) show massive growth potential in the areas of biomedical applications such as cell biology, medical stream, molecular biology, pharmacology, and healthcare product manufacturing. The application of both of these assemblies has seen enormous growth in recent years. In this focused review on DNA‐based supramolecular assemblies like hydrogels and dendrimers, we present the principles of synthesis and characterization, key developments with examples and applications, and conclude with a brief perspective on challenges and future outlook for such devices and their subsequent applications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Chemical Record Wiley

DNA Nanotechnology‐Based Supramolecular Assemblies for Targeted Biomedical Applications

The Chemical Record , Volume 22 (8) – Aug 1, 2022

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References (69)

Publisher
Wiley
Copyright
© 2022 The Chemical Society of Japan & Wiley‐VCH GmbH
ISSN
1527-8999
eISSN
1528-0691
DOI
10.1002/tcr.202200048
Publisher site
See Article on Publisher Site

Abstract

DNA is a polyanionic, hydrophilic, and natural biopolymer that offers properties such as biodegradability, biocompatibility, non‐toxicity, and non‐immunogenicity. These properties of DNA as an ideal biopolymer offer modern‐day researchers’ reasons to exploit these to form high‐order supramolecular assemblies. These structures could range from simple to complex and provide various applications. Among them, supramolecular assemblies like DNA hydrogels (DNA‐HG) and DNA dendrimers (DNA‐DS) show massive growth potential in the areas of biomedical applications such as cell biology, medical stream, molecular biology, pharmacology, and healthcare product manufacturing. The application of both of these assemblies has seen enormous growth in recent years. In this focused review on DNA‐based supramolecular assemblies like hydrogels and dendrimers, we present the principles of synthesis and characterization, key developments with examples and applications, and conclude with a brief perspective on challenges and future outlook for such devices and their subsequent applications.

Journal

The Chemical RecordWiley

Published: Aug 1, 2022

Keywords: DNA supramolecular assemblies; DNA hydrogels; DNA dendrimers; Aptamers; Biomedical Applications

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