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Ann. Hum. Genet. (1999), 63, 351±367 351 Printed in Great Britain European Mathematical Genetics Meeting held at Loughborough, 9±11 April 1999 ORGANISED BY NUALA A SHEEHAN AT THE DEPARTMENT OF MATHEMATICAL SCIENCES, LOUGHBOROUGH UNIVERSITY Abstracts Risk Models for Familial Breast and Ovarian Cancer. A. C. ANTONIOU", D. F. EASTON", S. A. GAYTHER#, J. F. STRATTON# and B. J. PONDER#. " CRC Genetic Epidemiology Unit, Institute of Public Health and # CRC Human Cancer Genetics Research Group, University of Cambridge, UK. We investigated risk models for the inherited susceptibility of breast and ovarian cancer, using data from both high-risk families and a population based series of ovarian cancer. The ®rst data set consisted of 112 families containing 2 or more relatives with epithelial ovarian cancer. BRCA1 and BRCA2 germline mutations were detected in 50 % of these families. The second study involved 374 ovarian cancer cases, collected at the Royal Marsden Hospital, London, who had DNA samples analysed for BRCA1 mutations. 12 women were found to be carriers. We constructed genetic models for ovarian and breast cancer using the computer program MENDEL. In the ®rst study we modelled the effects of BRCA1 and BRCA2 simultaneously and allowed for a third
Annals of Human Genetics – Wiley
Published: Jan 1, 1999
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