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Disparate effects of long‐term potentiation on evoked potentials and single CA1 neurons in the hippocampus of anesthetized rats

Disparate effects of long‐term potentiation on evoked potentials and single CA1 neurons in the... To examine the effects of long‐term potentiation (LTP) on individual neurons in the intact brain, anesthetized rats were implanted with a recording stereotrode in the right CA1 layer of the hippocampus and a stimulating electrode in the right and left CA3 layers. The evoked and spontaneous firing of single CA1 neurons was characterized before and after LTP of the contralateral (commissural) Schaffer collaterals and again after LTP of the ipsilateral (associational) Schaffer collaterals. Individual CA1 neurons displayed either increases or decreases in evoked and spontaneous firing after LTP. As many as five discriminated cells were recorded simultaneously, and they typically responded discordantly, so that after LTP, firing in some neurons increased while in others it decreased. The response of individual neurons to in vivo LTP may be modulated by heterogeneous synaptic changes on individual and local groups of cells, and by changes in feed‐forward excitation and inhibition provided by local hippocampal circuitry. Hippocampus 10:207–212, 2000 © 2000 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hippocampus Wiley

Disparate effects of long‐term potentiation on evoked potentials and single CA1 neurons in the hippocampus of anesthetized rats

Hippocampus , Volume 10 (3) – Jan 1, 2000

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References (25)

Publisher
Wiley
Copyright
Copyright © 2000 Wiley‐Liss, Inc.
ISSN
1050-9631
eISSN
1098-1063
DOI
10.1002/1098-1063(2000)10:3<207::AID-HIPO1>3.0.CO;2-S
pmid
10902890
Publisher site
See Article on Publisher Site

Abstract

To examine the effects of long‐term potentiation (LTP) on individual neurons in the intact brain, anesthetized rats were implanted with a recording stereotrode in the right CA1 layer of the hippocampus and a stimulating electrode in the right and left CA3 layers. The evoked and spontaneous firing of single CA1 neurons was characterized before and after LTP of the contralateral (commissural) Schaffer collaterals and again after LTP of the ipsilateral (associational) Schaffer collaterals. Individual CA1 neurons displayed either increases or decreases in evoked and spontaneous firing after LTP. As many as five discriminated cells were recorded simultaneously, and they typically responded discordantly, so that after LTP, firing in some neurons increased while in others it decreased. The response of individual neurons to in vivo LTP may be modulated by heterogeneous synaptic changes on individual and local groups of cells, and by changes in feed‐forward excitation and inhibition provided by local hippocampal circuitry. Hippocampus 10:207–212, 2000 © 2000 Wiley‐Liss, Inc.

Journal

HippocampusWiley

Published: Jan 1, 2000

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