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Digestive tract neoplasms in young individuals: Demographics, staging and risk factors

Digestive tract neoplasms in young individuals: Demographics, staging and risk factors INTRODUCTIONCancer trends in young adults over the last few decades demonstrate significantly increased incidence of digestive tract neoplasm (DTN) including the upper gastrointestinal (UGI), lower gastrointestinal (LGI), hepatobiliary (HB) and pancreatic neoplasms.1 Traditionally, malignant neoplasms have particularly been thought to be a disease of the elderly individuals; however, it is surprising to observe the rising incidence of such neoplasms in young individuals (YI). According to a European study, the incidence of colorectal cancer (CRC) is increasing in Europe among subjects aged 20 to 49 years and the fastest rise is in the youngest age group.2 Rising frequency of DTN has also been observed in other countries of the world including United States, Canada, Australia and New Zealand.3‐7 Research shows that esophageal and gastric cancers are also becoming increasingly common in the young.8,9 Apart from the neoplasms of gastrointestinal origin, recent studies also reveal rising incidences of hepatobiliary neoplasms including hepatocellular cancer (HCC) and biliary tract cancers like gall bladder cancer and cholangiocarcinoma (CC) in young individuals.10,11Various diseases predispose to development of gastrointestinal (GI) and hepatobiliary (HB) neoplasms in young patients. For example, familial adenomatous polyposis (FAP) and Lynch syndrome are not only associated with CRC malignancies in young individuals but http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Reports Wiley

Digestive tract neoplasms in young individuals: Demographics, staging and risk factors

Cancer Reports , Volume 4 (2) – Apr 1, 2021

Digestive tract neoplasms in young individuals: Demographics, staging and risk factors

Cancer Reports , Volume 4 (2) – Apr 1, 2021

Abstract

INTRODUCTIONCancer trends in young adults over the last few decades demonstrate significantly increased incidence of digestive tract neoplasm (DTN) including the upper gastrointestinal (UGI), lower gastrointestinal (LGI), hepatobiliary (HB) and pancreatic neoplasms.1 Traditionally, malignant neoplasms have particularly been thought to be a disease of the elderly individuals; however, it is surprising to observe the rising incidence of such neoplasms in young individuals (YI). According to a European study, the incidence of colorectal cancer (CRC) is increasing in Europe among subjects aged 20 to 49 years and the fastest rise is in the youngest age group.2 Rising frequency of DTN has also been observed in other countries of the world including United States, Canada, Australia and New Zealand.3‐7 Research shows that esophageal and gastric cancers are also becoming increasingly common in the young.8,9 Apart from the neoplasms of gastrointestinal origin, recent studies also reveal rising incidences of hepatobiliary neoplasms including hepatocellular cancer (HCC) and biliary tract cancers like gall bladder cancer and cholangiocarcinoma (CC) in young individuals.10,11Various diseases predispose to development of gastrointestinal (GI) and hepatobiliary (HB) neoplasms in young patients. For example, familial adenomatous polyposis (FAP) and Lynch syndrome are not only associated with CRC malignancies in young individuals but

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References (38)

Publisher
Wiley
Copyright
© 2021 Wiley Periodicals LLC.
eISSN
2573-8348
DOI
10.1002/cnr2.1319
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONCancer trends in young adults over the last few decades demonstrate significantly increased incidence of digestive tract neoplasm (DTN) including the upper gastrointestinal (UGI), lower gastrointestinal (LGI), hepatobiliary (HB) and pancreatic neoplasms.1 Traditionally, malignant neoplasms have particularly been thought to be a disease of the elderly individuals; however, it is surprising to observe the rising incidence of such neoplasms in young individuals (YI). According to a European study, the incidence of colorectal cancer (CRC) is increasing in Europe among subjects aged 20 to 49 years and the fastest rise is in the youngest age group.2 Rising frequency of DTN has also been observed in other countries of the world including United States, Canada, Australia and New Zealand.3‐7 Research shows that esophageal and gastric cancers are also becoming increasingly common in the young.8,9 Apart from the neoplasms of gastrointestinal origin, recent studies also reveal rising incidences of hepatobiliary neoplasms including hepatocellular cancer (HCC) and biliary tract cancers like gall bladder cancer and cholangiocarcinoma (CC) in young individuals.10,11Various diseases predispose to development of gastrointestinal (GI) and hepatobiliary (HB) neoplasms in young patients. For example, familial adenomatous polyposis (FAP) and Lynch syndrome are not only associated with CRC malignancies in young individuals but

Journal

Cancer ReportsWiley

Published: Apr 1, 2021

Keywords: digestive tract neoplasms; gastrointestinal neoplasms; hepatobiliary neoplasms; young individuals

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