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Differentiation of the PGM 2 locus isozymes from those of PGM 1 and PGM 3 in terms of phosphopentomutase activity

Differentiation of the PGM 2 locus isozymes from those of PGM 1 and PGM 3 in terms of... BY CHRISTINE B. QUICK, RACHEL A. FISHER AND HARRY HARRIS M R C Human Biochemical Genetics Unit, Galton Laboratory, University College London Three separate and not closely linked loci, designated PGM,, PGM, and PGM,, determine the series of isozymes with phosphoglucomutase activity which occur in man (Spencer, Hopkinson & Harris 1964; Hopkinson & Harris 1965, 1966, 1968; Parrington et al. 1968).Each locus determines a characteristic set of two or three isozymes, and electrophoretic variants attributable t o the occurrence of alleles at each of the loci have been identified. The relative electrophoretic mobilities towards the anode of the three sets of isozymes are in the order PGM, < PGM, < PGM,. I n most tissues the PGM, isozymes account for between 85 yoand 95 % of the total phosphoglucomutase activity. Red cells are the exception because here the total PGM activity is attributable in about equal proportions to PGM, and PGM, isozymes (McAlpine, Hopkinson & Harris 1970a). Studies of molecular size both by gel filtration (Monn, 1969; McAlpine, Hopkinson & Harris, 1970b) and by ultracentrifugation (Santiachiara & Modiano, 1969) indicate that the PGM, isozymes are somewhat larger than those of PGM, or PGM,. Investigation of the relative heat, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Differentiation of the PGM 2 locus isozymes from those of PGM 1 and PGM 3 in terms of phosphopentomutase activity

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Publisher
Wiley
Copyright
Copyright © 1972 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1957.tb01869.x
Publisher site
See Article on Publisher Site

Abstract

BY CHRISTINE B. QUICK, RACHEL A. FISHER AND HARRY HARRIS M R C Human Biochemical Genetics Unit, Galton Laboratory, University College London Three separate and not closely linked loci, designated PGM,, PGM, and PGM,, determine the series of isozymes with phosphoglucomutase activity which occur in man (Spencer, Hopkinson & Harris 1964; Hopkinson & Harris 1965, 1966, 1968; Parrington et al. 1968).Each locus determines a characteristic set of two or three isozymes, and electrophoretic variants attributable t o the occurrence of alleles at each of the loci have been identified. The relative electrophoretic mobilities towards the anode of the three sets of isozymes are in the order PGM, < PGM, < PGM,. I n most tissues the PGM, isozymes account for between 85 yoand 95 % of the total phosphoglucomutase activity. Red cells are the exception because here the total PGM activity is attributable in about equal proportions to PGM, and PGM, isozymes (McAlpine, Hopkinson & Harris 1970a). Studies of molecular size both by gel filtration (Monn, 1969; McAlpine, Hopkinson & Harris, 1970b) and by ultracentrifugation (Santiachiara & Modiano, 1969) indicate that the PGM, isozymes are somewhat larger than those of PGM, or PGM,. Investigation of the relative heat,

Journal

Annals of Human Genetics – Wiley

Published: Apr 1, 1972

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