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J. Leaney, Andrew Tinker (2000)
The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel.Proceedings of the National Academy of Sciences of the United States of America, 97 10
W. Jarolimek, J. Bäurle, U. Misgeld (1998)
Pore Mutation in a G-Protein-Gated Inwardly Rectifying K+ Channel Subunit Causes Loss of K+-Dependent Inhibition in weaver HippocampusThe Journal of Neuroscience, 18
C. Lüscher, L. Jan, M. Stoffel, R. Malenka, R. Nicoll (1997)
G Protein-Coupled Inwardly Rectifying K+ Channels (GIRKs) Mediate Postsynaptic but Not Presynaptic Transmitter Actions in Hippocampal NeuronsNeuron, 19
E. Neher (1992)
Correction for liquid junction potentials in patch clamp experiments.Methods in enzymology, 207
M. Abraham, A. Jahangir, A. Alekseev, A. Terzic (1999)
Channelopathies of inwardly rectifying potassium channelsThe FASEB Journal, 13
A. Inanobe, Y. Yoshimoto, Y. Horio, Ken-Ichiro Morishige, H. Hibino, S. Matsumoto, Y. Tokunaga, T. Maeda, Yutaka Hata, Y. Takai, Y. Kurachi (1999)
Characterization of G-Protein-Gated K+ Channels Composed of Kir3.2 Subunits in Dopaminergic Neurons of the Substantia NigraThe Journal of Neuroscience, 19
T. Pham, J. Lacaille (1996)
Multiple postsynaptic actions of GABA via GABAB receptors on CA1 pyramidal cells of rat hippocampal slices.Journal of neurophysiology, 76 1
NG GORDONY.K., S. Bertrand, R. Sullivan, N. Éthier, Jennifer Wang, Jim Yergey, Michel Belley, L. Trimble, Kevin Bateman, L. Alder, Alison Smith, R. Mckernan, K. Metters, G. O'neill, J. Lacaille, T. Hébert (2001)
Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.Molecular pharmacology, 59 1
S. Blein, Edward Hawrot, Paul Barlow (2000)
The metabotropic GABA receptor: molecular insights and their functional consequencesCellular and Molecular Life Sciences CMLS, 57
The pre‐ and postsynaptic effects of baclofen, a broad‐spectrum γ‐aminobutyric acid (GABA)B receptor agonist, and gabapentin, a selective agonist at GABAB receptors composed of GABAB(1a,2) heterodimers, were examined in CA1 pyramidal cells using whole‐cell patch‐clamp recordings in hippocampal slices from different strains of mice. In slices from C57BL/6 mice, by means of GABAB receptors, gabapentin and baclofen activated outward K+ currents at resting membrane potential. In weaver mice with a Kir3.2 channel mutation, baclofen and gabapentin failed to activate postsynaptic K+ currents. However, in littermate controls of weaver mice, gabapentin failed to evoke K+ currents, whereas baclofen activated currents in the same cells. Thus, postsynaptic actions of gabapentin and baclofen on K+ currents are different in this mouse strain. Via presynaptic GABAB receptors, baclofen significantly reduced GABAA inhibitory postsynaptic currents (IPSCs) in slices from C57BL/6 mice, as well as weaver and control mice. In contrast, gabapentin did not affect IPSCs significantly in any group of mice. These results indicate that although baclofen and gabapentin are agonists at postsynaptic GABAB receptors positively coupled to K+ channels, their mechanism of action differs in certain strains of mice, including the weaver wild‐type mice, suggesting a dissociation in their signaling mechanism and coupling to K+ channels. Hippocampus 2003;13:525–528. © 2003 Wiley‐Liss, Inc.
Hippocampus – Wiley
Published: Jan 1, 2003
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