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Absence of erythrocytic components in the original K662 line
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Cellular localization of an Epstein‐Barr virus (EBV)‐associated complement‐fixing antigen in producer and non‐producer lymphoblastoid cell linesInternational Journal of Cancer, 11
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The deficiency of a lysosomal acid hydrolase in two clones derived from the human lymphoblastoid line F137 after mutagen treatmentAnnals of Human Genetics, 41
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Surface glycoprotein patterns of normal and malignant human lymphoid cells. I. T cells, T blasts and leukemic T cell linesInternational Journal of Cancer, 20
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Chromosome aberrations acquired in vilro by cells of human B lymphoid lines . I . Gains and losses of material
J. Evans, M. Steel, E. Arthur (1974)
A hemagglutination inhibition technique for detection of immunoglobulins in supernatants of human lymphoblastoid cell lines.Cell, 3 2
Y. Matsuoka, G. Moore, Y. Yagi, D. Pressman (1967)
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K. Nilsson, J. Pontén (1975)
Classification and biological nature of established human hematopoietic cell linesInternational Journal of Cancer, 15
A. Lelbovitz, W. Wright, S. Pathak, M. Siciliano, W. Daniels (1979)
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Establishment and characterisation of two unique cell lines
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Genetic studies on human lymphoblastoid lines: isozyme analysis on cell lines from forty‐one different individuals and on mutants produced following exposure to a chemical mutagenAnnals of Human Genetics, 36
E. Klein, George Klein, J. Nadkarni, J. Nadkarni, H. Wigzell, P. Clifford (1968)
Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines.Cancer research, 28 7
D. Swallow, S. Gardiner, H. Harris, E. Arthur, C. Steel, H. Evans (1977)
Lysosomal enzymes in human lymphoblastoid lines: unusual characteristics of RAJI and DAUDIAnnals of Human Genetics, 41
G. Foley, H. Lazarus, S. Farber, B. Uzman, B. Boone, R. McCarthy (1965)
Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemiaCancer, 18
Summary Isozymes determined by 11 loci have been examined in 137 human lymphoblastoid lines of various origins with a view to determining their phenotypic stability in culture. Lines of normal origin are stable and at these loci are phenotypically identical to the individuals from whom they are derived. Lymphomas and some lines from patients with leukaemias show a tendency to increased apparent homozygosity, presumably resulting from loss of expression of one or other allele during culture. Taken together with the cytogenetic evidence this suggests that progressive loss of functional parts of the genome with time in culture is a characteristic of lines derived from malignant lymphoid cells.
Annals of Human Genetics – Wiley
Published: Oct 1, 1980
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