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Defective tumor necrosis factor‐α production in infants with cow’s milk allergy

Defective tumor necrosis factor‐α production in infants with cow’s milk allergy As an aid to clarifying the role of immune mechanisms in the development of cow’s milk allergy (CMA) in suckling infants, we studied the capacity of peripheral blood mononuclear cells (PBMC) to produce tumor necrosis factor‐α (TNF‐α) in vitro. The study population consisted of 43 infants, aged 0.12–11.2 months; of these, 31 had challenge‐proven cow’s milk allergy manifested with either skin or gastrointestinal symptoms or both. In addition, 12 healthy infants were studied as controls. The spontaneous, unstimulated and mitogen‐induced production of TNF‐α and interferon‐γ (IFN‐γ) by isolated peripheral blood leukocytes was evaluated. TNF‐α and IFN‐γ production of PBMC was significantly lower in infants with cow’s milk allergy than in healthy children. Our results indicate that, in infants with CMA, the function of TNF‐α‐producing cells is defective. This might disturb the development of oral tolerance and thereby lead to cow’s milk allergy. These results may help to clarify the etiopathology of CMA. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Defective tumor necrosis factor‐α production in infants with cow’s milk allergy

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References (24)

Publisher
Wiley
Copyright
Copyright © 1999 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1034/j.1399-3038.1999.00034.x
Publisher site
See Article on Publisher Site

Abstract

As an aid to clarifying the role of immune mechanisms in the development of cow’s milk allergy (CMA) in suckling infants, we studied the capacity of peripheral blood mononuclear cells (PBMC) to produce tumor necrosis factor‐α (TNF‐α) in vitro. The study population consisted of 43 infants, aged 0.12–11.2 months; of these, 31 had challenge‐proven cow’s milk allergy manifested with either skin or gastrointestinal symptoms or both. In addition, 12 healthy infants were studied as controls. The spontaneous, unstimulated and mitogen‐induced production of TNF‐α and interferon‐γ (IFN‐γ) by isolated peripheral blood leukocytes was evaluated. TNF‐α and IFN‐γ production of PBMC was significantly lower in infants with cow’s milk allergy than in healthy children. Our results indicate that, in infants with CMA, the function of TNF‐α‐producing cells is defective. This might disturb the development of oral tolerance and thereby lead to cow’s milk allergy. These results may help to clarify the etiopathology of CMA.

Journal

Pediatric Allergy and Immunology – Wiley

Published: Aug 1, 1999

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