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Decreased brain serotonin transporter binding in ASD; intranasal oxytocin administration: effects on computerized social discrimination task and eye‐tracking

Decreased brain serotonin transporter binding in ASD; intranasal oxytocin administration: effects... Decreased Brain Serotonin Transporter Binding in ASD [Nakamura et al., 2010 ] Serotonin has been implicated in ASD since the initial report of increased serotonin in the blood of children with ASD in 1961 [Schain & Freedman, 1961 ]. After decades of investigation, the mechanism of the elevation in blood serotonin is not fully understood, although either reduced serotonin 5‐HT2 binding or increased serotonin transporter function were found in hyperserotonemic subjects in one study [Cook et al., 1993 ]. It is important to recognize that the peripheral serotonin increase applies only to a minority of subjects with ASD. Because of challenges in measuring central serotonin function in ASD, there have been few previous studies of serotonin in the brains of individuals with ASD. To date, in vivo study of serotonin in brain has been limited to studies in which radioactively tagged molecules (radioligands) that bind to serotonin proteins (serotonin receptors or transporters) are administered intravenously and taken into the brain where they bind to 5‐HT receptors (e.g. 5‐HT 2 ) or the 5‐HT transporter. SPECT or PET methods are then used to measure binding of the radioligands to the brain serotonin‐related proteins. The authors used the compound [ http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Autism Research Wiley

Decreased brain serotonin transporter binding in ASD; intranasal oxytocin administration: effects on computerized social discrimination task and eye‐tracking

Autism Research , Volume 3 (2) – Apr 1, 2010

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References (5)

Publisher
Wiley
Copyright
Copyright © 2010, International Society for Autism Research, Wiley Periodicals, Inc.
ISSN
1939-3792
eISSN
1939-3806
DOI
10.1002/aur.129
Publisher site
See Article on Publisher Site

Abstract

Decreased Brain Serotonin Transporter Binding in ASD [Nakamura et al., 2010 ] Serotonin has been implicated in ASD since the initial report of increased serotonin in the blood of children with ASD in 1961 [Schain & Freedman, 1961 ]. After decades of investigation, the mechanism of the elevation in blood serotonin is not fully understood, although either reduced serotonin 5‐HT2 binding or increased serotonin transporter function were found in hyperserotonemic subjects in one study [Cook et al., 1993 ]. It is important to recognize that the peripheral serotonin increase applies only to a minority of subjects with ASD. Because of challenges in measuring central serotonin function in ASD, there have been few previous studies of serotonin in the brains of individuals with ASD. To date, in vivo study of serotonin in brain has been limited to studies in which radioactively tagged molecules (radioligands) that bind to serotonin proteins (serotonin receptors or transporters) are administered intravenously and taken into the brain where they bind to 5‐HT receptors (e.g. 5‐HT 2 ) or the 5‐HT transporter. SPECT or PET methods are then used to measure binding of the radioligands to the brain serotonin‐related proteins. The authors used the compound [

Journal

Autism ResearchWiley

Published: Apr 1, 2010

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