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We report a direct and effective metal‐free α‐acylation of 2‐oxindoles using C‐acyl imidazolium salts as an acylating agent via C(O)−C bond cleavage. The mild reaction conditions, affordable base, additive‐free and simple substrates make this methodology very attractive for easy access to 3‐alkylidene oxindoles – privilege biologically active oxindole derivatives. The wide substrate scope and gram‐scale preparation are notable features of this methodology.
Asian Journal of Organic Chemistry – Wiley
Published: May 1, 2020
Keywords: ; ; ; ;
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