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DBU‐Promoted α‐Acylation of 2‐Oxindoles through Acyl C−C Bond Cleavage: Imidazolium Salts as an Emerging Acylating Agent

DBU‐Promoted α‐Acylation of 2‐Oxindoles through Acyl C−C Bond Cleavage: Imidazolium Salts as an... We report a direct and effective metal‐free α‐acylation of 2‐oxindoles using C‐acyl imidazolium salts as an acylating agent via C(O)−C bond cleavage. The mild reaction conditions, affordable base, additive‐free and simple substrates make this methodology very attractive for easy access to 3‐alkylidene oxindoles – privilege biologically active oxindole derivatives. The wide substrate scope and gram‐scale preparation are notable features of this methodology. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

DBU‐Promoted α‐Acylation of 2‐Oxindoles through Acyl C−C Bond Cleavage: Imidazolium Salts as an Emerging Acylating Agent

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References (42)

Publisher
Wiley
Copyright
© 2020 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.202000139
Publisher site
See Article on Publisher Site

Abstract

We report a direct and effective metal‐free α‐acylation of 2‐oxindoles using C‐acyl imidazolium salts as an acylating agent via C(O)−C bond cleavage. The mild reaction conditions, affordable base, additive‐free and simple substrates make this methodology very attractive for easy access to 3‐alkylidene oxindoles – privilege biologically active oxindole derivatives. The wide substrate scope and gram‐scale preparation are notable features of this methodology.

Journal

Asian Journal of Organic ChemistryWiley

Published: May 1, 2020

Keywords: ; ; ; ;

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