Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Data on linkage between the locus determining placental alkaline phosphatase ( Pl ) and other markers

Data on linkage between the locus determining placental alkaline phosphatase ( Pl ) and other... BY J. H. EDWARDS Department of Social Medicine, University of Birmingham JUNE WINGHAM Blood Transfusion Service, Birmingham AND The sib-pair method (Penrose 1935) provides a simple procedure for the detection of linkage, and, when only sib pairs are available, as in dissimilar twins, is particularly appropriate, although full efficiency can only be achieved by fairly complicated analysis. A scoring procedure for this purpose has been published (Penrose, 1953), but, although powerful in the detection of linkage, the estimation of linkage is considerably more complicated, and unbiased estimation may only be tractable by likelihood analysis due to the asymmetric nature of the likelihood distributions. Fig. 1. Card derived from two similar cards with marked-sensedata. (Availablefrom IBM subject to authors’ permission. Code 866-11846.) We present data showing, on simple sib-pair enumerations, no suggestion of linkage, or of non-independent segregation, between the locus determining the placental alkaline phosphatase system, sex, and the loci of eleven other markers. The data were obtained during a systematic study of placentation and zygosity of all twins born in Birmingham in 1964 and 1965, and all twins born in the major maternity centres between 1 January and 30 June 1966. Cord blood was grouped and further http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Data on linkage between the locus determining placental alkaline phosphatase ( Pl ) and other markers

Annals of Human Genetics , Volume 30 (3) – Jan 1, 1967

Loading next page...
 
/lp/wiley/data-on-linkage-between-the-locus-determining-placental-alkaline-S4z3hSxyOs

References (5)

Publisher
Wiley
Copyright
Copyright © 1967 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1967.tb00024.x
Publisher site
See Article on Publisher Site

Abstract

BY J. H. EDWARDS Department of Social Medicine, University of Birmingham JUNE WINGHAM Blood Transfusion Service, Birmingham AND The sib-pair method (Penrose 1935) provides a simple procedure for the detection of linkage, and, when only sib pairs are available, as in dissimilar twins, is particularly appropriate, although full efficiency can only be achieved by fairly complicated analysis. A scoring procedure for this purpose has been published (Penrose, 1953), but, although powerful in the detection of linkage, the estimation of linkage is considerably more complicated, and unbiased estimation may only be tractable by likelihood analysis due to the asymmetric nature of the likelihood distributions. Fig. 1. Card derived from two similar cards with marked-sensedata. (Availablefrom IBM subject to authors’ permission. Code 866-11846.) We present data showing, on simple sib-pair enumerations, no suggestion of linkage, or of non-independent segregation, between the locus determining the placental alkaline phosphatase system, sex, and the loci of eleven other markers. The data were obtained during a systematic study of placentation and zygosity of all twins born in Birmingham in 1964 and 1965, and all twins born in the major maternity centres between 1 January and 30 June 1966. Cord blood was grouped and further

Journal

Annals of Human GeneticsWiley

Published: Jan 1, 1967

There are no references for this article.