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Penrose Penrose (1935)
The detection of autosomal linkage in data which consist of pairs of brothers and sisters of unspecified parentageAnn. Eugen., Lond., 6
L. Penrose (1935)
THE DETECTION OF AUTOSOMAL LINKAGE IN DATA WHICH CONSIST OF PAIRS OF BROTHERS AND SISTERS OF UNSPECIFIED PARENTAGEAnnals of Human Genetics, 6
B. Woolf (1955)
ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASEAnnals of Human Genetics, 19
E. Robson, H. Harris (1967)
Further studies on the genetics of placental alkaline phosphataseAnnals of Human Genetics, 30
Penrose Penrose (1953)
The general purpose sib‐pair linkage testAnn. Eugen., Lond., 18
BY J. H. EDWARDS Department of Social Medicine, University of Birmingham JUNE WINGHAM Blood Transfusion Service, Birmingham AND The sib-pair method (Penrose 1935) provides a simple procedure for the detection of linkage, and, when only sib pairs are available, as in dissimilar twins, is particularly appropriate, although full efficiency can only be achieved by fairly complicated analysis. A scoring procedure for this purpose has been published (Penrose, 1953), but, although powerful in the detection of linkage, the estimation of linkage is considerably more complicated, and unbiased estimation may only be tractable by likelihood analysis due to the asymmetric nature of the likelihood distributions. Fig. 1. Card derived from two similar cards with marked-sensedata. (Availablefrom IBM subject to authorsâ permission. Code 866-11846.) We present data showing, on simple sib-pair enumerations, no suggestion of linkage, or of non-independent segregation, between the locus determining the placental alkaline phosphatase system, sex, and the loci of eleven other markers. The data were obtained during a systematic study of placentation and zygosity of all twins born in Birmingham in 1964 and 1965, and all twins born in the major maternity centres between 1 January and 30 June 1966. Cord blood was grouped and further
Annals of Human Genetics – Wiley
Published: Jan 1, 1967
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