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Allergic rhinitis is a particularly good model for studies of cytokine pro‐duction in vivo, in this study the occurrence of the cytokines IL‐4, IL‐5. IL‐10 and IFN‐yas well as the soluble receptor tbr IL‐4 in nasal lavage flu‐ids were assayed in 38 school children, with seasonal allergic rhinitis, and 19 healthy age matched, non atopic controls, using highly sensitive enzyme immunossays. IL‐4 levels in patients with seasonal allergie rhinitis were markedly increased in comparison with those in non‐atopic controls or in atopic pa‐tients before the start of the pollen season. In controls, but not in the atopic patients, levels of IFN‐yand IL‐5 were significantly higher in specimens obtained during the pollen season than in those obtained outside the season. The IL‐4/IFN‐y ratios were significantly higher in atopic than in nonalopic subjects and further increased in atopic patients during the season. In addition to IL‐4, elevated levels of IL‐10 were observed in association with seasonal rhinitis. Following treatment with a topical steroid (budeso nide) there was a statistically significant increase of the levels of soluble IL‐4 receptor. These findings indicate that nonatopic and atopic individuals react to pollen exposure with distinct cytokine patterns in agreement with the Thl/ Th2 concept. Topical steroids may possibly decrease inflammation by increasing the formation of soluble IL‐4 receptor.
Pediatric Allergy and Immunology – Wiley
Published: Aug 1, 1997
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