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Cysteinyl‐leukotrienes in nasal lavage fluid in children with asthma

Cysteinyl‐leukotrienes in nasal lavage fluid in children with asthma The aim of this study was to investigate repeatability of cysteinyl‐leukotrienes (cys‐LT) measurements in nasal lavage fluid (NLF) and to determine if cys‐LT levels in NLF are related to asthma severity in children. As a second outcome, we investigated if cys‐LT in NLF reflect lower airway inflammation as assessed by exhaled NO measurement. To assess the repeatability of cys‐LT measurements, two NLF samples were obtained from eight healthy controls 24 h apart. Sixty‐nine asthmatic children (mean age; range: 12.8; 7.3–17.7 yr), which were grouped according to asthma severity were studied cross‐sectionally on one occasion. Cys‐LT in NLF were analyzed using a specific enzyme immunoassay, exhaled NO, and pulmonary function parameters were measured. The coefficient of repeatability for the repeated cys‐LT measurements was 1.45 pg/ml. Cys‐LT levels in NLF differed significantly between asthma severity groups (p < 0.001): mild intermittent: (median (IQR)) 6.88 pg/ml (2.00–27.87); mild persistent: 21.09 pg/ml (4.50–84.67); and moderate persistent asthmatics: 36.41 pg/ml (11.03–118.40). Concentration of cys‐LT in NLF and exhaled NO was positively correlated (r = 0.85; p < 0.001). In conclusion, concentration of cys‐LT in NLF correlates with asthma severity in children and is related to lower airway inflammation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Cysteinyl‐leukotrienes in nasal lavage fluid in children with asthma

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References (37)

Publisher
Wiley
Copyright
© 2008 The Authors
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.2007.00614.x
pmid
18397406
Publisher site
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Abstract

The aim of this study was to investigate repeatability of cysteinyl‐leukotrienes (cys‐LT) measurements in nasal lavage fluid (NLF) and to determine if cys‐LT levels in NLF are related to asthma severity in children. As a second outcome, we investigated if cys‐LT in NLF reflect lower airway inflammation as assessed by exhaled NO measurement. To assess the repeatability of cys‐LT measurements, two NLF samples were obtained from eight healthy controls 24 h apart. Sixty‐nine asthmatic children (mean age; range: 12.8; 7.3–17.7 yr), which were grouped according to asthma severity were studied cross‐sectionally on one occasion. Cys‐LT in NLF were analyzed using a specific enzyme immunoassay, exhaled NO, and pulmonary function parameters were measured. The coefficient of repeatability for the repeated cys‐LT measurements was 1.45 pg/ml. Cys‐LT levels in NLF differed significantly between asthma severity groups (p < 0.001): mild intermittent: (median (IQR)) 6.88 pg/ml (2.00–27.87); mild persistent: 21.09 pg/ml (4.50–84.67); and moderate persistent asthmatics: 36.41 pg/ml (11.03–118.40). Concentration of cys‐LT in NLF and exhaled NO was positively correlated (r = 0.85; p < 0.001). In conclusion, concentration of cys‐LT in NLF correlates with asthma severity in children and is related to lower airway inflammation.

Journal

Pediatric Allergy and Immunology – Wiley

Published: May 1, 2008

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