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H. Rostami, L. Shiri (2018)
One-Pot Multicomponent Synthesis of Pyrrolo[1,2-a]pyrazines in Water Catalyzed by Fe3O4@SiO2-OSO3HChemistrySelect
Guoxi Xiong, Mohui Wei, Yirong Zhou, Yungui Li, Fang-Lin Zhang, Y. Gong (2011)
A Multicomponent Reaction between α-SubstitutedAcroleins, Nitroalkanes and Paraformaldehyde: Efficient Constructionof Nitro δ-LactolSynthesis, 2011
J. Biard, S. Guyot, C. Roussakis, J. Verbist, J. Vercauteren, J. Weber, K. Boukef (1994)
Lepadiformine, a new marine cytotoxic alkaloid from Clavelina lepadiformis MüllerTetrahedron Letters, 35
A. Köhler, G. Raabe, J. Runsink, F. Köhler, H. Gais (2014)
Sulfoximine‐Based Modular Enantioselective Synthesis of Azaspirocycles Featuring Sulfoximine Displacement, Dianion Cycloalkylation, RCM and N‐Acyliminium Ion FormationEuropean Journal of Organic Chemistry, 2014
Jing Wang, P. Herdewijn (1999)
Enantioselective synthesis and conformational study of cyclohexene carbocyclic nucleosidesJournal of Organic Chemistry, 64
M. Yeh, Chengtao Fang, H. Lin (2012)
Facile synthesis of azaspirocycles via iron trichloride-promoted cyclization/chlorination of cyclic 8-aryl-5-aza-5-tosyl-2-en-7-yn-1-ols.Organic letters, 14 7
Zhongli Xu, P. Xing, B. Jiang (2017)
Intramolecular Aza-Piancatelli Rearrangement of Alkyl- or Arylamines Promoted by PPh3/Diethyl Azodicarboxylate.Organic letters, 19 5
Xue Yang, Yu-Chen Zhang, Qiuhua Zhu, Man‐Su Tu, F. Shi (2016)
Diastereo- and Enantioselective Construction of the Hexahydrocoumarin Scaffold via an Organocatalytic Asymmetric [3 + 3] Cyclization.The Journal of organic chemistry, 81 12
Li Li, Qi Chen, X. Xiong, Chuang Zhang, Jingjing Qian, Jie Shi, Qiong An, Ming Zhang (2018)
Synthesis of polysubstituted pyrroles via a gold(I)-catalyzed tandem three-component reaction at room temperatureChinese Chemical Letters
M. Reetz (1999)
Synthesis and diastereoselective reactions of n,n-dibenzylamino aldehydes and related compounds.Chemical reviews, 99 5
W. Unsworth, R. Taylor (2016)
Direct Imine Acylation: A Versatile Method for the Synthesis of Nitrogen-Containing Heterocycles, Spirocycles and Natural ProductsSynlett, 27
Carine Guérot, Boris Tchitchanov, H. Knust, E. Carreira (2011)
Synthesis of novel angular spirocyclic azetidines.Organic letters, 13 4
K. Ding, Zhaobin Han, Zheng Wang (2009)
Spiro skeletons: a class of privileged structure for chiral ligand design.Chemistry, an Asian journal, 4 1
Jungui Zhang, Juan Yao, Jiamin Liu, Shuwen Xue, Yang Li, Cunde Wang (2015)
Four-component reaction between naphthols, substituted β-nitrostyrenes, substituted benzaldehydes and ammonium acetate in water–PEG-400: an approach to construct polysubstituted naphthofuranaminesRSC Advances, 5
Peter Finkbeiner, Nicole Weckenmann, B. Nachtsheim (2014)
Alkynyliodonium salt mediated alkynylation of azlactones: fast access to C(α)-tetrasubstituted α-amino acid derivatives.Organic letters, 16 5
Manuela Weber, W. Frey, R. Peters (2013)
Catalytic asymmetric synthesis of spirocyclic azlactones by a double Michael-addition approach.Chemistry, 19 25
Attila Sveiczer, A. North, N. Mateu, S. Kidd, H. Sore, D. Spring (2019)
Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection.Organic letters
S. Tallon, F. Manoni, S. Connon (2015)
A practical aryl unit for azlactone dynamic kinetic resolution: orthogonally protected products and a ligation-inspired coupling process.Angewandte Chemie, 54 3
Giuditta Guazzelli, Lorna Duffy, D. Procter (2008)
A Samarium(II)-mediated, stereoselective cyclization for the synthesis of azaspirocycles.Organic letters, 10 19
Xushun Qing, Ting-Yu Wang, Fei-Yu Zhang, Cunde Wang (2016)
One-pot synthesis of 2,4,6-triarylpyridines from β-nitrostyrenes, substituted salicylic aldehydes and ammonium acetateRSC Advances, 6
Manuela Weber, R. Peters (2012)
Pd(II)-catalyzed regio-, enantio-, and diastereoselective 1,4-addition of azlactones formed in situ from racemic unprotected amino acids and acetic anhydride.The Journal of organic chemistry, 77 23
Jiří Mikušek, J. Ward, M. Banwell (2019)
Electrocyclic Ring-Opening of 6,6-Dichlorobicyclo[3.1.0]-hexanes and Trapping of the Resulting π-Allyl Cations by C-1 Tethered Hydroxyamine Derivatives: Formation of 2-Oxa-1-azaspiro[4.5]decan-3-onesAustralian Journal of Chemistry
R. Funk, J. Daggett (1987)
Intermolecular cycloaddition reactions of exocyclic nitrones facile: synthesis of 1-azaspirocyclesHeterocycles, 26
Yan Li, Zhi-Yong Xue, Weijian Ye, Juanjuan Liu, Juan Yao, Cunde Wang (2014)
One-pot multicomponent synthesis of highly functionalized piperidines from substituted β-nitrostyrenes, Meldrum's acid, aromatic aldehydes, and ammonium acetate.ACS combinatorial science, 16 3
Hua Zhang, Ya Li, Fanghui Xu, Xinfeng Ren, Le Wang, P. Zhou, Zhihua Sun (2012)
Stereoselective Synthesis of γ,δ-Unsaturated β-Amino Sulfones from Ellman’s N-tert-Butylsulfinyl Ketimines and Methyl Phenyl SulfoneSynlett, 23
C. Rodríguez-García, J. Ibarzo, A. Alvarez-Larena, V. Branchadell, A. Oliva, R. Ortuño (2001)
Stereoselective synthesis of chiral polyfunctionalized cyclohexane derivatives. Palladium(II)-mediated reaction between cyclohexenones and diazomethaneTetrahedron, 57
Weijian Ye, Lanxiang Zhou, Shuwen Xue, Yang Li, Cunde Wang (2015)
Bimolecular Intermolecular-Michael/Intramolecular-Michael/Aromatization Reaction of 1-Cyanocyclopropane 1-Esters or 1,1-Dicyanocyclopropanes: A Straightforward Approach to Fully Substituted BenzenesSynlett, 26
Adinarayana Akondi, Sowmya Mekala, M. Kantam, Rajiv Trivedi, L. Chowhan, Amitava Das (2017)
An expedient microwave assisted regio- and stereoselective synthesis of spiroquinoxaline pyrrolizine derivatives and their AChE inhibitory activityNew Journal of Chemistry, 41
Ying-Hui Huang, Yi-Xin Huang, Jing Sun, Chaoguo Yan (2019)
A [3+2] cycloaddition reaction for the synthesis of spiro[indoline-3,3′-pyrrolidines] and evaluation of cytotoxicity towards cancer cellsNew Journal of Chemistry
Weihua Shi, Zhigan Jiang, Haiying He, Fubiao Xiao, F. Lin, Ya Sun, Lijuan Hou, Liang Shen, Lixia Han, M. Zeng, K. Lai, Z. Gu, Xinsheng Chen, Taoqian Zhao, Li Guo, Chun Yang, Jian Li, Shuhui Chen (2018)
Discovery of 3,3'-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection.ACS medicinal chemistry letters, 9 2
James Sahn, D. Comins (2010)
[2 + 2] Photochemical cycloaddition/ring opening of 6-alkenyl-2,3-dihydro-4-pyridones.The Journal of organic chemistry, 75 19
Jing Sun, Yu Zhang, Rong-Guo Shi, Chaoguo Yan (2019)
Selective synthesis of spirooxindoles via a two-step reaction of N-phenacylpyridinium bromide, 1,3-indanedione and N-alkylisations.Organic & biomolecular chemistry, 17 16
H. Liu, Zhengquan Zhou, Qian Sun, Yun Li, Yan Li, Jinliang Liu, Peiyun Yan, Dan Wang, Cunde Wang (2012)
Synthesis of polysubstituted 2-piperidinones via a Michael addition/nitro-Mannich/lactamization cascade.ACS combinatorial science, 14 6
M. Hapke (2016)
Transition metal-free formal [2+2+2] cycloaddition reactions of alkynesTetrahedron Letters, 57
Jun Zhu, Y. Cheng, Xiao-Kang Kuang, Lijia Wang, Zhong-Bo Zheng, Yong Tang (2016)
Highly Efficient Formal [2+2+2] Strategy for the Rapid Construction of Polycyclic Spiroindolines: A Concise Synthesis of 11-Demethoxy-16-epi-myrtoidine.Angewandte Chemie, 55 32
Wenjun Li, Xianhong Xu, Yang Liu, Hua Gao, Yuyu Cheng, Pengfei Li (2018)
Enantioselective Organocatalytic 1,6-Addition of Azlactones to para-Quinone Methides: An Access to α,α-Disubstituted and β,β-Diaryl-α-amino acid Esters.Organic letters, 20 4
Masayuki Kobayashi, T. Suda, K. Noguchi, Ken Tanaka (2011)
Enantioselective construction of bridged multicyclic skeletons: intermolecular [2+2+2] cycloaddition/intramolecular Diels-Alder reaction cascade.Angewandte Chemie, 50 7
S. Arai, Arisa Izaki, Yuka Amako, Masaya Nakajima, M. Uchiyama, A. Nishida (2019)
Regioselective [2+2+2] Cycloaddition Reaction Using Allene‐ynes with Simple Allenes under Nickel CatalysisAdvanced Synthesis & Catalysis
Leoni Palmer, Javier Alaniz (2011)
Direct and highly diastereoselective synthesis of azaspirocycles by a dysprosium(III) triflate catalyzed aza-Piancatelli rearrangement.Angewandte Chemie, 50 31
A. Ding, M. Meazza, Hao Guo, J. Yang, R. Rios (2018)
New development in the enantioselective synthesis of spiro compounds.Chemical Society reviews, 47 15
K. Tsuchikama, Y. Kuwata, T. Shibata (2006)
Highly enantioselective construction of a chiral spirocyclic structure by the [2 + 2 + 2] cycloaddition of diynes and exo-methylene cyclic compounds.Journal of the American Chemical Society, 128 42
Zhen Wang, N. Spiccia, Christopher Gartshore, Jayamini Illesinghe, W. Jackson, A. Robinson (2013)
A concise cross-metathesis route to enantiopure 1-azaspirocyclesSynthesis, 45
Rongfang Liu, Zifeng Qin, B. Fan, Ruifeng Li, R. Zhou, Zhengjie He (2019)
Phosphine-Catalyzed Chemo- and Diastereoselective [2 + 2 + 2] and [3 + 2] Annulations of γ-Methyl Allenoates with Doubly Activated Olefins: Syntheses of Highly Substituted Cyclohexanes and Cyclopentenes.The Journal of organic chemistry
De Wang, Yin Wei, Min Shi (2012)
Construction of adjacent spiro-quaternary and tertiary stereocenters through phosphine-catalyzed asymmetric [3+2] annulation of allenoates with alkylidene azlactones.Chemical communications, 48 22
A. Saha, Soumen Payra, Sohel Akhtar, Subhash Banerjee (2017)
Fabrication of Nano‐CuO@ZnO for the Synthesis of Functionalized β‐Enaminone Derivatives from β‐Nitrostyrenes, Aliphatic/Aromatic Amines and 1,3‐Dicarbonyl/4‐Hydroxy Coumarin, 2
Jiang Cheng, Xiao Zheng, Pei‐Qiang Huang (2019)
Construction of multifunctional heterocycles bearing aza-quaternary carbons by titanocene-catalyzed umpolung reactionsTetrahedron
S. Carey, M. Aratani, Y. Kishi (1985)
A total synthesis of d,1-histrionicotoxinTetrahedron Letters, 26
R. Rios (2012)
Enantioselective methodologies for the synthesis of spiro compounds.Chemical Society reviews, 41 3
T. Chou, M. Kuramoto, Y. Otani, M. Shikano, K. Yazawa, D. Uemura (1996)
Pinnaic acid and tauropinnaic acid: Two novel fatty acids composing a 6-azaspiro[4.5]decane unit from the Okinawan bivalve Pinna muricataTetrahedron Letters, 37
Aaron Smith, Shawn Cabral, D. Kung, Colin Rose, James Southers, Carmen Garcia-Irizarry, D. Damon, S. Bagley, D. Griffith (2016)
The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems.The Journal of organic chemistry, 81 9
Bingjie Liu, Yueteng Zhang, Gang Huang, Xinting Zhang, Pengfei Niu, Jie Wu, Wenquan Yu, Junbiao Chang (2014)
A concise approach to polysubstituted oxazoles from N-acyl-2-bromo enamides via a copper(I)/amino acid-catalyzed intramolecular C-O bond formation.Organic & biomolecular chemistry, 12 23
Qun Cai, Dengke Li, Rongrong Zhou, Shiyi Zhuang, Jin-Tian Ma, Yan‐Dong Wu, A. Wu (2016)
Acid-Catalyzed Multicomponent Tandem Double Cyclization: A One-pot, Metal-free Route to Synthesize Polyfunctional 4,9-Dihydropyrrolo[2,1-b]quinazolines.The Journal of organic chemistry, 81 17
Manuela Weber, S. Jautze, W. Frey, R. Peters (2010)
Bispalladacycle-catalyzed Brønsted acid/base-promoted asymmetric tandem azlactone formation-Michael addition.Journal of the American Chemical Society, 132 35
B. Shafiee, J. Duffield, Rudy Timm, R. Liyanage, J. Lay, A. Khosropour, H. Rudbari, M. Beyzavi (2019)
Metal-free and benign approach for the synthesis of dihydro-5′H-spiro[benzo[c]chromene-8,4′-oxazole]-5′,6(7H)-dione scaffolds as masked amino acidsGreen Chemistry
Qun Cai, Dengke Li, Rongrong Zhou, Wen-Ming Shu, Yan‐Dong Wu, A. Wu (2016)
Acid-Catalyzed Multicomponent Tandem Cyclizations: Access to Polyfunctional Dihydroindolizino[8,7-b]indoles.Organic letters, 18 6
B. Wagner, W. Hiller, H. Ohno, N. Krause (2016)
Gold-catalyzed three-component spirocyclization: a one-pot approach to functionalized pyrazolidines.Organic & biomolecular chemistry, 14 5
G. Dake (2006)
Recent Approaches to the Construction of 1-Azaspiro[4.5]decanes and Related 1-AzaspirocyclesChemInform, 37
A. Avenoza, J. Busto, M. París, J. Peregrina, C. Cativiela (1997)
THE USE OF 4-HETARYLIDEN- AND 4-ARYLIDEN-5(4H)-OXAZOLONES AS DIENOPHILES. APPROPRIATE REAGENTS FOR THE SYNTHESIS OF CYCLIC ANALOGUES OF NATURAL AMINO ACIDSJournal of Heterocyclic Chemistry, 34
Suvi Orr, Ramsay Beveridge, S. Bhattacharya, K. Cameron, S. Coffey, D. Fernando, D. Hepworth, M. Jackson, Vishal Khot, R. Kosa, K. Lapham, P. Loria, K. McClure, Jigna Patel, Colin Rose, James Saenz, I. Stock, G. Storer, Maria Volkenburg, D. Vrieze, Guoqiang Wang, Jun Xiao, Yingxin Zhang (2015)
Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists.ACS medicinal chemistry letters, 6 2
Kai-Jiong Xiao, Jie Luo, Xiao-Er Xia, Yu Wang, Pei‐Qiang Huang (2013)
General one-pot reductive gem-bis-alkylation of tertiary lactams/amides: rapid construction of 1-azaspirocycles and formal total synthesis of (±)-cephalotaxine.Chemistry, 19 39
Xifu Liang, J. Andersch, M. Bols (2002)
Garner's aldehydeJournal of The Chemical Society-perkin Transactions 1
Jing Sun, Wang Jiang, Chaoguo Yan (2019)
Convenient construction of dibenzo[b,d]furanes and 2,6-diaryl-4-(2-hydroxyphenyl)pyridines via domino reaction of pyridinium ylides with 2-aryl-3-nitrochromenesOrganic Chemistry Frontiers
Li Yuan, Shengdong Jiang, Zeng-Zeng Li, Yong‐Ming Zhu, Jian Yu, Lan Li, Ming-Zhu Li, Shi Tang, Ruiying Sheng (2018)
Photocatalyzed cascade Meerwein addition/cyclization of N-benzylacrylamides toward azaspirocycles.Organic & biomolecular chemistry, 16 14
Wu-Bang Tang, K. Cao, Shanshui Meng, Wenhua Zheng (2017)
Boronic Acid Catalysis for Aza-Piancatelli RearrangementSynthesis, 49
Dimitris Kalaitzakis, Eirini Antonatou, G. Vassilikogiannakis (2014)
One-pot synthesis of 1-azaspiro frameworks initiated by photooxidation of simple furans.Chemical communications, 50 4
Shuwen Xue, Juan Yao, Jiamin Liu, Lizhong Wang, Xinyu Liu, Cunde Wang (2016)
Three-component reaction between substituted 2-(2-nitrovinyl)-phenols, acetylenedicarboxylate and amines: diversity-oriented synthesis of novel pyrrolo[3,4-c]coumarinsRSC Advances, 6
Chen Tan, Weijian Ye, Juan Yao, Juanjuan Liu, Shuwen Xue, Yang Li, Cunde Wang (2015)
Efficient strategy for construction of 6-carbamoylfulvene-6-carboxylate skeletons via [3 + 2] cycloaddition of 1-cyanocyclopropane 1-ester with β-nitrostyrenesRSC Advances, 5
Chenlu Dai, Mingshuang Li, Meng-Yan Chen, Naili Luo, Cunde Wang (2019)
Novel synthesis of highly functionalized cyclopentane derivatives via [3 + 2] cycloaddition reactions of donor–acceptor cyclopropanes and (E)-3-aryl-2-cyanoacrylatesJournal of Chemical Research, 43
Juan Yao, Xinliang Shen, Chen Tan, Cunde Wang (2015)
Three-Component Reaction from But-2-Ynedioate, Triphenylphosphine, and Substituted Chalcones: to Access Highly Substituted (Triphenylphosphoranylidene) CyclopentadienecarboxylatesPhosphorus, Sulfur, and Silicon and the Related Elements, 190
Jianmin Zhang, H. Pettersson, C. Huitema, Chunying Niu, Jiang Yin, M. James, L. Eltis, J. Vederas (2007)
Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters.Journal of medicinal chemistry, 50 8
J. Jurczak, A. Gołębiowski (1989)
Optically active N-protected .alpha.-amino aldehydes in organic synthesisChemical Reviews, 89
P. Wipf, Corey Stephenson, M. Walczak (2004)
Diversity-oriented synthesis of azaspirocycles.Organic letters, 6 17
Keiichi Yamada, Shun-suke Shinoda, H. Oku, K. Komagoe, T. Katsu, R. Katakai (2006)
Synthesis of low-hemolytic antimicrobial dehydropeptides based on gramicidin s.Journal of medicinal chemistry, 49 26
Ting-Yu Wang, Xushun Qing, Chenlu Dai, Zhenjie Su, Cunde Wang (2018)
Regioselective construction of 1,3-diaryl tetrahydroindazolones via the three-component reaction of 1,3-cyclohexanediones, β-nitrostyrenes and arylhydrazines.Organic & biomolecular chemistry, 16 14
Johannes Burkhard, Björn Wagner, H. Fischer, F. Schuler, K. Müller, E. Carreira (2010)
Synthesis of azaspirocycles and their evaluation in drug discovery.Angewandte Chemie, 49 20
L. Tietze, S. Dietz, N. Böhnke, M. Düfert, Ina Objartel, D. Stalke (2011)
Three‐Component Domino Knoevenagel/Hetero‐Diels–Alder Reaction for the Synthesis of the Amino Sugars 2‐Acetoxyforosamine and 2‐Acetoxyossamine – Experimental and Theoretical ResultsEuropean Journal of Organic Chemistry, 2011
Wangze Song, Wei Lu, J. Wang, P. Lu, Yanguang Wang (2010)
A facile route to gamma-nitro imidates via four-component reaction of alkynes with sulfonyl azides, alcohols, and nitroolefins.The Journal of organic chemistry, 75 10
Danielle Pinheiro, E. Ávila, Gabriel Batista, G. Amarante (2017)
Chemoselective Reduction of Azlactones Using Schwartz's Reagent.The Journal of organic chemistry, 82 11
Oskari Karjalainen, A. Koskinen (2012)
Diastereoselective synthesis of vicinal amino alcohols.Organic & biomolecular chemistry, 10 22
Pramod Chopade, J. Louie (2006)
[2+2+2] Cycloaddition Reactions Catalyzed by Transition Metal ComplexesAdvanced Synthesis & Catalysis, 348
A. Avenoza, J. Barriobero, C. Cativiela, Miguel Fernández-Recio, J. Peregrina, F. Rodríguez (2001)
New synthesis of all four 1-amino-2-hydroxycyclohexanecarboxylic acidsTetrahedron, 57
Y. Tsuda (1996)
Chapter 4 – Erythrina and Related Alkaloids, 48
Weijian Ye, Yan Li, Lanxiang Zhou, Juanjuan Liu, Cunde Wang (2015)
Three-component reaction between substituted β-nitrostyrenes, β-dicarbonyl compounds and amines: diversity-oriented synthesis of novel β-enaminonesGreen Chemistry, 17
C. Tran, M. Haddad, V. Ratovelomanana-Vidal (2019)
Ruthenium-Catalyzed, Microwave-Mediated [2+2+2] Cycloaddition: A Useful Combination for the Synthesis of 2-AminopyridinesSynlett, 30
A. Culf, Daniel Leger, Martin Léger, R. Ouellette, D. Barnett, M. Touaibia (2016)
Zwitterionic Azaspirocyclic HydantoinsLetters in Organic Chemistry, 13
An eco‐friendly, straightforward, and three‐component [2+2+2] cycloaddition reaction of 4‐aryliden‐2‐phenyl‐5(4H)‐oxazolones and substituted β‐nitrostyrenes to construct diversified 3‐oxa‐1‐azaspiro[4.5]dec‐1‐en‐4‐ones has been developed with good yields and regio‐ and diastereoselectivity. This reaction proceeds via a one‐pot [2+2+2] cycloaddition utilizing cesium carbonate as a promoter and shows high atom economy under the reaction conditions.
Asian Journal of Organic Chemistry – Wiley
Published: Jan 1, 2020
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