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(2009)
DNA gyrase A subunit-simocyclinone D8 complex Acta Cryst
- Publisher
- Wiley
- Copyright
- International Union of Crystallography, 2009
- ISSN
- 1744-3091
- eISSN
- 1744-3091
- DOI
- 10.1107/S1744309109028097
- pmid
- 19652356
- Publisher site
- See Article on Publisher Site
Abstract
Crystals of a complex formed between the 59 kDa N‐terminal fragment of the Escherichia coli DNA gyrase A subunit (also known as the breakage–reunion domain) and the antibiotic simocyclinone D8 were grown by vapour diffusion. The complex crystallized with I‐centred orthorhombic symmetry and X‐ray data were recorded to a resolution of 2.75 Å from a single crystal at the synchrotron. DNA gyrase is an essential bacterial enzyme and thus represents an attractive target for drug development.
Journal
Acta Crystallographica Section F – Wiley
Published: Aug 1, 2009