Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/crystal-structure-of-full-length-zika-virus-ns5-protein-reveals-a-vCz8zYPKlp
References (50)
-
(2017)
Antiviral Res -
S. Weaver, F. Costa, M. Garcia-Blanco, A. Ko, G. Ribeiro, G. Saade, P. Shi, N. Vasilakis (2016)
Zika virus: History, emergence, biology, and prospects for control.Antiviral research, 130
-
V. Klema, Mengyi Ye, A. Hindupur, T. Teramoto, Keerthi Gottipati, R. Padmanabhan, K. Choi (2016)
Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase InterfacePLoS Pathogens, 12
-
L. Eyer, Radim Nencka, Ivana Huvarová, Martin Palus, M. Alves, E. Gould, E. Clercq, D. Růžek (2016)
Nucleoside Inhibitors of Zika Virus.The Journal of infectious diseases, 214 5
-
M. Cunha, D. Espósito, I. Rocco, A. Maeda, F. Vasami, J. Nogueira, R. Souza, A. Suzuki, M. Addas-Carvalho, M. Barjas-Castro, M. Resende, R. Stucchi, I. Boin, G. Katz, R. Angerami, B. Fonseca (2016)
First Complete Genome Sequence of Zika Virus (Flaviviridae, Flavivirus) from an Autochthonous Transmission in BrazilGenome Announcements, 4
-
S. Lim, Louis-Sebastian Sonntag, C. Noble, S. Nilar, Rusinova Ng, Gang Zou, P. Monaghan, Ka Chung, Hongping Dong, Bo-ping Liu, C. Bodenreider, Gladys Lee, Mei Ding, W. Chan, Gang Wang, Yap Jian, A. Chao, J. Lescar, Zheng Yin, T. Vedananda, T. Keller, P. Shi (2010)
Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase*The Journal of Biological Chemistry, 286
-
P. Garcez, E. Loiola, R. Costa, L. Higa, P. Trindade, R. Delvecchio, J. Nascimento, R. Brindeiro, A. Tanuri, S. Rehen (2016)
Zika virus impairs growth in human neurospheres and brain organoidsScience, 352
-
E. Decroly, F. Ferron, J. Lescar, B. Canard (2011)
Conventional and unconventional mechanisms for capping viral mRNANature Reviews. Microbiology, 10
-
(2011)
Acta Cryst -
(2002)
EMBO J -
(2016)
Am. J. Med. Sci -
G. Carteaux, M. Maquart, A. Bedet, D. Contou, P. Brugières, S. Fourati, L. Langavant, T. Broucker, C. Brun-Buisson, I. Leparc-Goffart, A. Dessap (2016)
Zika Virus Associated with Meningoencephalitis.The New England journal of medicine, 374 16
-
J. Julander, V. Siddharthan, Joseph Evans, Ray Taylor, Kelsey Tolbert, Chad Apuli, J. Stewart, Preston Collins, M. Gebre, S. Neilson, A. Wettere, Young-Min Lee, W. Sheridan, J. Morrey, Y. Babu (2017)
Efficacy of the broad‐spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse modelAntiviral Research, 137
-
B. Bynum, H. Bynum (2015)
LancetThe Lancet, 386
-
J. Lessler, L. Chaisson, L. Kucirka, Qifang Bi, K. Grantz, H. Salje, H. Salje, Andrea Carcelen, C. Ott, J. Sheffield, N. Ferguson, D. Cummings, C. Metcalf, I. Rodríguez-Barraquer (2016)
Assessing the global threat from Zika virusScience, 353
-
D. Gor, David Lee, V. Emery (1996)
J. Virol. MethodsJournal of Virological Methods, 62
-
P. Emsley, B. Lohkamp, William Scott, K. Cowtan (2010)
Features and development of CootActa Crystallographica Section D: Biological Crystallography, 66
-
G. Lu, P. Gong (2013)
Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase InterfacePLoS Pathogens, 9
-
(2016)
N. Engl. J. Med -
(2016)
Cell. Rep -
(2015)
Proc. Natl Acad. Sci. USA -
(2016)
Science -
(2016)
PLoS Pathog -
Biological Crystallography Data Processing and Analysis with the Autoproc Toolbox -
M. Giangaspero, R. Harasawa, A. Zanetti (2008)
Taxonomy of genus Hepacivirus. Application of palindromic nucleotide substitutions for the determination of genotypes of human hepatitis C virus species.Journal of virological methods, 153 2
-
(2016)
J. Med. Virol -
N. Broutet, F. Krauer, Maurane Riesen, A. Khalakdina, M. Almiron, S. Aldighieri, M. Espinal, N. Low, C. Dye (2016)
Zika Virus as a Cause of Neurologic Disorders.The New England journal of medicine, 374 16
-
E. Sesmero, Ian Thorpe (2015)
Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and DynamicsViruses, 7
-
Yongqian Zhao, T. Soh, Jie Zheng, K. Chan, W. Phoo, Chin Lee, Moon Tay, K. Swaminathan, T. Cornvik, S. Lim, P. Shi, J. Lescar, S. Vasudevan, D. Luo (2015)
A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus ReplicationPLoS Pathogens, 11
-
(2016)
J. Infect. Dis. BMC Infect. Dis -
Fatiha Benmansour, I. Trist, B. Coutard, E. Decroly, G. Quérat, A. Brancale, K. Barral (2017)
Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.European journal of medicinal chemistry, 125
-
M. Egloff, D. Benarroch, B. Selisko, J. Romette, B. Canard (2002)
An RNA cap (nucleoside‐2′‐O‐)‐methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterizationThe EMBO Journal, 21
-
(2011)
Nature Rev. Microbiol -
Full-length Zika virus NS5 protein 121 -
P. Hotez, A. Fenwick, L. Savioli, D. Molyneux (2009)
Rescuing the bottom billion through control of neglected tropical diseasesThe Lancet, 373
-
H. Malet, N. Massé, B. Selisko, J. Romette, K. Alvarez, J. Guillemot, H. Tolou, Thai Yap, Subashri Vasudevan, J. Lescar, B. Canard (2008)
The flavivirus polymerase as a target for drug discovery.Antiviral research, 80 1
-
L. Furuya-Kanamori, S. Liang, G. Milinovich, R. Magalhaes, A. Clements, Wenbiao Hu, P. Brasil, F. Frentiu, R. Dunning, L. Yakob (2016)
Co-distribution and co-infection of chikungunya and dengue virusesBMC Infectious Diseases, 16
-
Yongqian Zhao, T. Soh, S. Lim, Ka Chung, K. Swaminathan, S. Vasudevan, P. Shi, J. Lescar, D. Luo (2015)
Molecular basis for specific viral RNA recognition and 2′-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)Proceedings of the National Academy of Sciences, 112
-
M. Winn, C. Ballard, K. Cowtan, E. Dodson, P. Emsley, P. Evans, R. Keegan, E. Krissinel, A. Leslie, A. Mccoy, S. McNicholas, G. Murshudov, N. Pannu, E. Potterton, H. Powell, R. Read, A. Vagin, K. Wilson (2011)
Overview of the CCP4 suite and current developmentsActa Crystallographica Section D: Biological Crystallography, 67
-
O. Smart, T. Womack, C. Flensburg, P. Keller, W. Paciorek, A. Sharff, C. Vonrhein, G. Bricogne (2012)
Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTERActa Crystallographica Section D: Biological Crystallography, 68
-
Javier Coloma, R. Jain, K. Rajashankar, A. García-Sastre, A. Aggarwal (2016)
Structures of NS5 Methyltransferase from Zika VirusCell reports, 16
-
A. Hajra, D. Bandyopadhyay, S. Hajra (2016)
Zika Virus: A Global Threat to Humanity: A Comprehensive Review and Current DevelopmentsNorth American Journal of Medical Sciences, 8
-
Jennifer Govero, P. Esakky, S. Scheaffer, Estefania Fernandez, A. Drury, Derek Platt, M. Gorman, Justin Richner, Elizabeth Caine, Vanessa Salazar, K. Moley, M. Diamond (2016)
Zika virus infection damages the testes in miceNature, 540
-
Van-Mai Cao-Lormeau, A. Blake, S. Mons, S. Lastère, C. Roche, J. Vanhomwegen, T. Dub, Laure Baudouin, A. Teissier, P. Larre, Anne-Laure Vial, C. Decam, V. Choumet, S. Halstead, H. Willison, L. Musset, J. Manuguerra, P. Desprès, E. Fournier, H. Mallet, D. Musso, A. Fontanet, J. Neil, F. Ghawché (2016)
Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control studyThe Lancet, 387
-
W. Team (2016)
After Ebola in West Africa — Unpredictable Risks, Preventable EpidemicsThe New England Journal of Medicine, 375
-
Abdo Elfiky (2016)
Zika viral polymerase inhibition using anti‐HCV drugs both in market and under clinical trialsJournal of Medical Virology, 88
-
(2011)
J. Biol. Chem -
Thai Yap, Ting Xu, Yen-Liang Chen, H. Malet, M. Egloff, B. Canard, S. Vasudevan, J. Lescar (2007)
Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom ResolutionJournal of Virology, 81
-
(2016)
Genome Announc -
Yongqian Zhao, T. Soh, K. Chan, S. Fung, K. Swaminathan, S. Lim, P. Shi, T. Huber, J. Lescar, D. Luo, S. Vasudevan (2015)
Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus ReplicationJournal of Virology, 89
- Publisher
- Wiley
- Copyright
- Copyright © 2017 Wiley Subscription Services
- ISSN
- 2053-230X
- eISSN
- 2053-230X
- DOI
- 10.1107/S2053230X17001601
- pmid
- 28291746
- Publisher site
- See Article on Publisher Site
Abstract
The rapid spread of the recent Zika virus (ZIKV) epidemic across various countries in the American continent poses a major health hazard for the unborn fetuses of pregnant women. To date, there is no effective medical intervention. The nonstructural protein 5 of Zika virus (ZIKV‐NS5) is critical for ZIKV replication through the 5′‐RNA capping and RNA polymerase activities present in its N‐terminal methyltransferase (MTase) and C‐terminal RNA‐dependent RNA polymerase (RdRp) domains, respectively. The crystal structure of the full‐length ZIKV‐NS5 protein has been determined at 3.05 Å resolution from a crystal belonging to space group P21212 and containing two protein molecules in the asymmetric unit. The structure is similar to that reported for the NS5 protein from Japanese encephalitis virus and suggests opportunities for structure‐based drug design targeting either its MTase or RdRp domain.
Journal
Acta Crystallographica Section F – Wiley
Published: Jan 1, 2017
Keywords: ; ;