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- Publisher
- Wiley
- Copyright
- Copyright © 2015 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 2193-5807
- eISSN
- 2193-5815
- DOI
- 10.1002/ajoc.201590004
- Publisher site
- See Article on Publisher Site
Abstract
Intracellular, reduction‐responsive, copolymer micelles have been developed for targeted anticancer drug delivery by Yanli Zhao et al. In their Full paper on page 226, they present copolymer micelles that show a promising potential for targeted anticancer applications. The anticancer drug doxorubicin is encapsulated into the micelles during the micellization of the polymer, and then released rapidly into the environment under the stimulus of an intracellular reducing agent. Flow cytometry and confocal laser scanning microscopy observations indicate that the drug is successfully released from the internalized micelles into the cytoplasm, inducing apoptosis and cell death.
Journal
Asian Journal of Organic Chemistry – Wiley
Published: Mar 1, 2015
Keywords: ; ; ; ;