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Cover Picture: Enantioselective Syntheses of α‐Silyl Amines via a Copper‐N‐Heterocyclic Carbene Catalyzed Nucleophilic Silicon Transfer to Imines (Asian J. Org. Chem. 8/2014)

Cover Picture: Enantioselective Syntheses of α‐Silyl Amines via a Copper‐N‐Heterocyclic Carbene... Chiral α‐silyl amines are important bioactive agents as well as building blocks for the preparation of unnatural peptides and proteins. In their Communication paper on page 851 ff, Wei He and co‐workers have developed an enantioselective synthesis of chiral α‐silyl amines via silylation of aldimines using the readily available CuCl/NaOtBu/chiral‐N‐heterocyclic carbene catalyst system and the commercially available Suginome Me2PhSiBpin reagent (pin=pinacolato). This method gives excellent enantiomeric excess up to 99% and has a wide substrate scope of 15 examples. The asymmetric silylation of ketimines was also explored. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

Cover Picture: Enantioselective Syntheses of α‐Silyl Amines via a Copper‐N‐Heterocyclic Carbene Catalyzed Nucleophilic Silicon Transfer to Imines (Asian J. Org. Chem. 8/2014)

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Publisher
Wiley
Copyright
Copyright © 2014 Wiley Subscription Services, Inc., A Wiley Company
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.201490016
Publisher site
See Article on Publisher Site

Abstract

Chiral α‐silyl amines are important bioactive agents as well as building blocks for the preparation of unnatural peptides and proteins. In their Communication paper on page 851 ff, Wei He and co‐workers have developed an enantioselective synthesis of chiral α‐silyl amines via silylation of aldimines using the readily available CuCl/NaOtBu/chiral‐N‐heterocyclic carbene catalyst system and the commercially available Suginome Me2PhSiBpin reagent (pin=pinacolato). This method gives excellent enantiomeric excess up to 99% and has a wide substrate scope of 15 examples. The asymmetric silylation of ketimines was also explored.

Journal

Asian Journal of Organic ChemistryWiley

Published: Aug 1, 2014

Keywords: ; ; ; ;

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