Cover Picture: Enantioselective Syntheses of α‐Silyl Amines via a Copper‐N‐Heterocyclic Carbene Catalyzed Nucleophilic Silicon Transfer to Imines (Asian J. Org. Chem. 8/2014)
Cover Picture: Enantioselective Syntheses of α‐Silyl Amines via a Copper‐N‐Heterocyclic Carbene...
Zhao, Chunliang; Jiang, Chenran; Wang, Jing; Wu, Cai; Zhang, Qing‐Wei; He, Wei
2014-08-01 00:00:00
Chiral α‐silyl amines are important bioactive agents as well as building blocks for the preparation of unnatural peptides and proteins. In their Communication paper on page 851 ff, Wei He and co‐workers have developed an enantioselective synthesis of chiral α‐silyl amines via silylation of aldimines using the readily available CuCl/NaOtBu/chiral‐N‐heterocyclic carbene catalyst system and the commercially available Suginome Me2PhSiBpin reagent (pin=pinacolato). This method gives excellent enantiomeric excess up to 99% and has a wide substrate scope of 15 examples. The asymmetric silylation of ketimines was also explored.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngAsian Journal of Organic ChemistryWileyhttp://www.deepdyve.com/lp/wiley/cover-picture-enantioselective-syntheses-of-silyl-amines-via-a-copper-quzE0I0LIN
Cover Picture: Enantioselective Syntheses of α‐Silyl Amines via a Copper‐N‐Heterocyclic Carbene Catalyzed Nucleophilic Silicon Transfer to Imines (Asian J. Org. Chem. 8/2014)
Chiral α‐silyl amines are important bioactive agents as well as building blocks for the preparation of unnatural peptides and proteins. In their Communication paper on page 851 ff, Wei He and co‐workers have developed an enantioselective synthesis of chiral α‐silyl amines via silylation of aldimines using the readily available CuCl/NaOtBu/chiral‐N‐heterocyclic carbene catalyst system and the commercially available Suginome Me2PhSiBpin reagent (pin=pinacolato). This method gives excellent enantiomeric excess up to 99% and has a wide substrate scope of 15 examples. The asymmetric silylation of ketimines was also explored.
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