Access the full text.
Sign up today, get DeepDyve free for 14 days.
E. Lander, L. Kruglyak (1995)
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage resultsNature Genetics, 11
R. Cottingham, R. Idury, A. Schäffer (1993)
Faster sequential genetic linkage computations.American journal of human genetics, 53 1
G. Lathrop, J. Lalouel, C. Julier, J. Ott (1984)
Strategies for multilocus linkage analysis in humans.Proceedings of the National Academy of Sciences of the United States of America, 81 11
The dissection of complex traits frequently calls for multiple analyses to be performed, including the use of both multiple phenotypes and genetic models. These multiple phenotypes and models are often not independent, and hence the necessary correction for the multiple testing is not straightforward. In this paper we offer a new approach to address the problem of how to correct for non‐independent multiple analyses in genomewide linkage studies. We describe one method of how to determine the number of ‘effectively independent’ tests performed in a linkage study using simple linear regression techniques. Further we describe how to use such information to establish genomewide significance thresholds for infinitely dense genomewide maps.
Annals of Human Genetics – Wiley
Published: Jan 1, 2001
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.