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- Publisher
- Wiley
- Copyright
- Copyright © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
- ISSN
- 2192-6506
- eISSN
- 2192-6506
- DOI
- 10.1002/cplu.201402436
- Publisher site
- See Article on Publisher Site
Abstract
Surface modification of silica nanoparticles (SiNPs) inside living cells was conducted by using the copper‐free bioorthogonal click reaction to evaluate the effects of surface chemical structures on dynamic behavior and excretion of SiNPs. The results demonstrated the spatial translocation of intracellular SiNPs to the plasma membrane upon surface modification in situ with phospholipids. Moreover, the extent and kinetics of excretion of the SiNPs from inside the cell were enhanced by modification.
Journal
ChemPlusChem – Wiley
Published: May 1, 2015