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Palmaz Palmaz, Garcia Garcia, Kopp Kopp (1987)
Balloon expandable intra‐arterial stents: The effect of anticoagulation on thrombus formation (abstract)Circulation, 76
Alerander Clowes, Morris Karnowsky (1977)
Suppression by heparin of smooth muscle cell proliferation in injured arteriesNature, 265
Freidman Freidman, Stemerman Stemerman, Wenz Wenz (1977)
The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbitsJ Clin Invest, 60
D. Holmes, R. Vlietstra, Hugh Smith, G. Vetrovec, K. Kent, M. Cowley, D. Faxon, A. Gruentzig, S. Kelsey, K. Detre, M. Raden, M. Mock (1984)
Restenosis after percutaneous transluminal coronary angioplasty (PTCA): a report from the PTCA Registry of the National Heart, Lung, and Blood Institute.The American journal of cardiology, 53 12
P. Serruys, B. Strauss, K. Beatt, M. Bertrand, J. Puel, A. Rickards, B. Meier, J. Goy, P. Vogt, L. Kappenberger, U. Sigwart (1991)
Angiographic follow-up after placement of a self-expanding coronary-artery stent.The New England journal of medicine, 324 1
Puel Puel, Rousseau Rousseau, Joffre Joffre (1987)
Intravascular stents to prevent restenosis after transluminal coronary angioplasty (abstract)Circulation, 76
J. Castellot, D. Cochran, M. Karnovsky (1985)
Effect of heparin on vascular smooth muscle cells. I. Cell metabolismJournal of Cellular Physiology, 124
Stephen Ellis, G. Roubin, J. Wilentz, J. Douglas, S. King (1989)
Effect of 18- to 24-hour heparin administration for prevention of restenosis after uncomplicated coronary angioplasty.American heart journal, 117 4
L. Jonasson, J. Holm, G. Hansson (1988)
Cyclosporin A inhibits smooth muscle proliferation in the vascular response to injury.Proceedings of the National Academy of Sciences of the United States of America, 85 7
Gimple Gimple, Owen Owen, Lodge Lodge (1990)
Reduction in angioplasty restenosis in rabbits by chronic subcutaneous heparin with or without intramural heparin delivery (abstract)Circulation, 82
J. Powell, J. Clozel, R. Müller, H. Kuhn, F. Hefti, M. Hosang, H. Baumgartner (1989)
Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury.Science, 245 4914
R. Schatz, D. Baim, M. Leon, S. Ellis, S. Goldberg, J. Hirshfeld, M. Cleman, H. Cabin, C. Walker, Jody Stagg, M. Buchbinder, P. Teirstein, E. Topol, M. Savage, J. Pérez, R. Curry, H. Whitworth, J. Sousa, F. Tio, Y. Almagor, R. Ponder, I. Penn, B. Leonard, S. Levine, R. Fish, J. Palmaz (1991)
Clinical Experience With the Palmaz‐Schatz Coronary Stent: Initial Results of a Multicenter StudyCirculation, 83
Marc Levine, Bradley Leonard, James Burke, Ira Nash, Robert Safian, Daniel Diver, D. Baim (1990)
Clinical and angiographic results of balloon-expandable intracoronary stents in right coronary artery stenoses.Journal of the American College of Cardiology, 16 2
U. Sigwart, P. Urban, S. Golf, U. Kaufmann, Christian Imbert, A. Fischer, L. Kappenberger (1988)
Emergency stenting for acute occlusion after coronary balloon angioplasty.Circulation, 78 5 Pt 1
Robert, J., Friedman, Michael, B., Stemerman, Barry Wenz, Sean Moore, Jack Gauldie, Michael Gent, Melvin, L. Tiell, Theodore, H. Spaet (1977)
The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization.The Journal of clinical investigation, 60 5
Chapman Chapman, Lim Lim, Gammon Gammon (1991)
An interventional approach to coronary gene transfer (abstract)Circulation, 84
P. Serruys, H. Luijten, K. Beatt, R. Geuskens, P. Feyter, M. Brand, Johan Reiber, H. Katen, G. Es, P. Hugenholtz (1988)
Incidence of restenosis after successful coronary angioplasty: a time-related phenomenon. A quantitative angiographic study in 342 consecutive patients at 1, 2, 3, and 4 months.Circulation, 77 2
Whitworth Whitworth, Roubin Roubin, Hollman Hollman (1986)
Effect of nifedipine in recurrent stenosis after percutaneous coronary angioplastyJ Am Coll Cardiol, 8
J. Castellot, M. Karnovsky, D. Beeler, R. Rosenberg (1984)
Structural determinants of the capacity of heparin to inhibit the proliferation of vascular smooth muscle cellsJournal of Cellular Physiology, 120
Sarembock Sarembock, Gertz Gertz, Gimple Gimple (1990)
Angiographic and pathologic study of the effect of recombinant desulphatohirudin on restenosis following angioplasty in rabbits (abstract)Circulation, 82
Annette Larsen, Dennis Lund, Robert Langer, Judah FOLKMANt (1986)
Oral heparin results in the appearance of heparin fragments in the plasma of rats.Proceedings of the National Academy of Sciences of the United States of America, 83 9
M. Liu, G. Roubin, K. Robinson, A. Black, J. Hearn, R. Siegel, S. King (1990)
Trapidil in preventing restenosis after balloon angioplasty in the atherosclerotic rabbit.Circulation, 81 3
J. Guyton, R. Rosenberg, A. Clowes, M. Karnovsky (1980)
Inhibition of Rat Arterial Smooth Muscle Cell Proliferation by Heparin: In Vivo Studies with Anticoagulant and Nonanticoagulant HeparinCirculation Research, 46
Leung Leung, Kaplan Kaplan, Grant Grant (1990)
Local delivery of antithrombin agent reduces platelet deposition at the site of balloon angioplasty (abstract)Circulation, 82
U. Sigwart, J. Puel, V. Mirkovitch, F. Joffre, L. Kappenberger (1987)
Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty.The New England journal of medicine, 316 12
R. Schatz, J. Palmaz, Francisco García, O. Garcia, S. Reuter (1987)
Balloon-expandable intracoronary stents in the adult dog.Circulation, 76 2
P. Urban, U. Sigwart, S. Golf, U. Kaufmann, H. Sadeghi, L. Kappenberger (1989)
Intravascular stenting for stenosis of aortocoronary venous bypass grafts.Journal of the American College of Cardiology, 13 5
Bailey Bailey, Guy Guy, Garcia Garcia (1990)
Polymer coating of Palmaz‐Schatz stent attenuates vascular spasm after stent placement (abstract)Circulation, 82
K. Lehmann, R. Doria, J. Feuer, P. Hall, D. Hoang (1991)
Paradoxical increase in restenosis rate with chronic heparin use: Final results of a randomized trialJournal of the American College of Cardiology, 17
Cavender Cavender, Anderson Anderson, Roubin Roubin (1990)
The effects of heparin bonded tantalum stents on thrombosis and neointimal proliferation (abstract)Circulation, 82
Cox Cox, Anderson Anderson, Roubin Roubin (1991)
Local delivery of heparin and methotrexate fails to inhibit in vivo smooth muscle cell proliferation (abstract)Circulation, 84
P. Henry, K. Bentley (1981)
Suppression of atherogenesis in cholesterol-fed rabbit treated with nifedipine.The Journal of clinical investigation, 68 5
Giessen Giessen, Strauss Strauss, Van Beusekom Van Beusekom (1990)
Self‐expandable mesh stents: An experimental study comparing polymer coated and uncoated stents in the coronary circulation of pigs (abstract)Circulation, 82
Serruys Serruys, Strauss Strauss, Beatt Beatt (1991)
Angiographic follow‐up of a self‐expanding coronary‐artery stentN Engl J Med, 324
Muller Muller, Topol Topol, Abrams Abrams (1990)
Intramural methotrexate therapy for the prevention of intimal proliferation following porcine carotid balloon angioplasty (abstract)Circulation, 82
Stephen Ellis, G. Roubin, S. King, J. Douglas, R. Shaw, S. Stertzer, R. Myler (1988)
In-hospital cardiac mortality after acute closure after coronary angioplasty: analysis of risk factors from 8,207 procedures.Journal of the American College of Cardiology, 11 2
H. Whitworth, G. Roubin, J. Hollman, B. Meier, P. Leimgruber, J. Douglas, S. King, A. Gruentzig (1986)
Effect of nifedipine on recurrent stenosis after percutaneous transluminal coronary angioplasty.Journal of the American College of Cardiology, 8 6
Serruys Serruys, Luijten Luijten, Beatt Beatt (1988)
Incidence of restenosis after successful coronary angioplasty: A time related phenomenonCirculation, 77
K. Robinson, G. Roubin, R. Siegel, A. Black, R. Apkarian, S. King (1988)
Intra-arterial stenting in the atherosclerotic rabbit.Circulation, 78 3
E. Edelman, Adams Dh, Morris Karnovsky (1990)
Effect of controlled adventitial heparin delivery on smooth muscle cell proliferation following endothelial injury.Proceedings of the National Academy of Sciences of the United States of America, 87
Stephen Ellis, G. Roubin, S. King, J. Douglas, W. Weintraub, Ronald Thomas, W. Cox (1988)
Angiographic and clinical predictors of acute closure after native vessel coronary angioplasty.Circulation, 77 2
Huber Huber, Schwartz Schwartz, Edwards Edwards (1991)
Neointimal proliferation is proportional to severity of coronary artery injury: Results in a porcine model (abstract)Restenosis Summit III, 5
Percutaneous coronary angioplasty is limited by neointimal hyperplasia and restenosis. Endovascular stenting has been proposed as a possible means of limiting this process. In practice stents have achieved early patency but are beset by early thrombosis and late restenosis. Heparin administered locally or systemically reduces smooth muscle cell hyperplasia following arterial injury in animals. Balloon‐expandable stainless steel stents were placed in de‐endothelialized rabbit iliac arteries to determine whether heparin released locally from perivascular matrices could reduce stent induced thrombosis and intimal hyperplasia. All animals received oral aspirin beginning 1 day prior to implantation and an IV bolus of heparin at balloon injury and stent placement. Heparin releasing ethylene‐vinyl acetate copolymer matrices were placed adjacent to the stented portion of the artery in the treated group of rabbits. Thrombosis was evident in 30% of ten control arteries 14 days after stent placement and was reduced to 0% in nine segments receiving local heparin therapy (P < 0.05). Intimal hyperplasia was present in all experimental arterial sections, but total intimal area normalized for induced injury was reduced at 14 days from 12.6 ± 0.9 mm2 in controls, to 6.8 ± 1.0 mm2 in treated arteries (P < 0.001). Our results with perivascular drug administration may shed some light on the pathobiology of the vascular response to endovascular stent insertion and might assist in the design of novel means for enhancing the utilization of angioplasty and other interventional procedures.
Journal of Interventional Cardiology – Wiley
Published: Sep 1, 1992
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