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Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation

Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation The effects of selective ibotenate lesions of the complete hippocampus (CHip), the hippocampal ventral pole (VP), or the medial prefrontal cortex (mPFC) in male rats were assessed on several measures related to energy regulation (i.e., body weight gain, food intake, body adiposity, metabolic activity, general behavioral activity, conditioned appetitive responding). The testing conditions were designed to minimize the nonspecific debilitating effects of these surgeries on intake and body weight. Rats with CHip and VP lesions exhibited significantly greater weight gain and food intake compared with controls. Furthermore, CHip‐lesioned rats, but not rats with VP lesions, showed elevated metabolic activity, general activity in the dark phase of the light‐dark cycle, and greater conditioned appetitive behavior, compared with control rats without these brain lesions. In contrast, rats with mPFC lesions were not different from controls on any of these measures. These results indicate that hippocampal damage interferes with energy and body weight regulation, perhaps by disrupting higher‐order learning and memory processes that contribute to the control of appetitive and consummatory behavior. © 2008 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hippocampus Wiley

Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation

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References (94)

Publisher
Wiley
Copyright
Copyright © 2008 Wiley‐Liss, Inc.
ISSN
1050-9631
eISSN
1098-1063
DOI
10.1002/hipo.20499
pmid
18831000
Publisher site
See Article on Publisher Site

Abstract

The effects of selective ibotenate lesions of the complete hippocampus (CHip), the hippocampal ventral pole (VP), or the medial prefrontal cortex (mPFC) in male rats were assessed on several measures related to energy regulation (i.e., body weight gain, food intake, body adiposity, metabolic activity, general behavioral activity, conditioned appetitive responding). The testing conditions were designed to minimize the nonspecific debilitating effects of these surgeries on intake and body weight. Rats with CHip and VP lesions exhibited significantly greater weight gain and food intake compared with controls. Furthermore, CHip‐lesioned rats, but not rats with VP lesions, showed elevated metabolic activity, general activity in the dark phase of the light‐dark cycle, and greater conditioned appetitive behavior, compared with control rats without these brain lesions. In contrast, rats with mPFC lesions were not different from controls on any of these measures. These results indicate that hippocampal damage interferes with energy and body weight regulation, perhaps by disrupting higher‐order learning and memory processes that contribute to the control of appetitive and consummatory behavior. © 2008 Wiley‐Liss, Inc.

Journal

Hippocampus – Wiley

Published: Mar 1, 2009

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