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Contrast‐Induced Nephropathy Remains a Serious Complication of PCI

Contrast‐Induced Nephropathy Remains a Serious Complication of PCI Although it is rare in the general population (<1%), contrast‐induced nephropathy (CIN) is a major cause of acute renal failure in cardiac patients, resulting in high in‐hospital mortality and poor long‐term survival following coronary intervention. The inherent risks involved with CIN make understanding the predictors and preventive strategies important for interventionalists in managing their patients. Incidence/Risk Factors CIN is defined as new‐onset or an exacerbation of renal dysfunction after contrast administration in the absence of other causes. The condition is marked by an increase of >25% or an absolute increase of >0.5 mg/dL in baseline serum creatinine. Symptoms occur 24–48 hours after contrast exposure, with creatinine peaking 5–7 days later and normalizing within 7–10 days in most cases. CIN is the third most common cause of hospital‐acquired renal failure, affecting half of patients with both renal insufficiency and diabetes. There are both patient‐ and procedure‐related risk factors for CIN ( Table 1 ). 1 Risk Factors for CIN Patient‐Related Risk Factors Procedure‐Related Risk Factors • Renal insufficiency Multiple contrast media injection within 72 hours • Diabetes mellitus with renal insufficiency Intra‐arterial injection site • Age High volume of contrast media • Volume depletion High osmolality of contrast media http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Interventional Cardiology Wiley

Contrast‐Induced Nephropathy Remains a Serious Complication of PCI

MEHRAN, ROXANA
Journal of Interventional Cardiology , Volume 20 (3) – Jun 1, 2007
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References (16)

Publisher
Wiley
Copyright
Copyright © 2007 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0896-4327
eISSN
1540-8183
DOI
10.1111/j.1540-8183.2007.00260.x
pmid
17524117
Publisher site
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Abstract

Although it is rare in the general population (<1%), contrast‐induced nephropathy (CIN) is a major cause of acute renal failure in cardiac patients, resulting in high in‐hospital mortality and poor long‐term survival following coronary intervention. The inherent risks involved with CIN make understanding the predictors and preventive strategies important for interventionalists in managing their patients. Incidence/Risk Factors CIN is defined as new‐onset or an exacerbation of renal dysfunction after contrast administration in the absence of other causes. The condition is marked by an increase of >25% or an absolute increase of >0.5 mg/dL in baseline serum creatinine. Symptoms occur 24–48 hours after contrast exposure, with creatinine peaking 5–7 days later and normalizing within 7–10 days in most cases. CIN is the third most common cause of hospital‐acquired renal failure, affecting half of patients with both renal insufficiency and diabetes. There are both patient‐ and procedure‐related risk factors for CIN ( Table 1 ). 1 Risk Factors for CIN Patient‐Related Risk Factors Procedure‐Related Risk Factors • Renal insufficiency Multiple contrast media injection within 72 hours • Diabetes mellitus with renal insufficiency Intra‐arterial injection site • Age High volume of contrast media • Volume depletion High osmolality of contrast media

Journal

Journal of Interventional Cardiology – Wiley

Published: Jun 1, 2007

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