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Construction of CF3‐containing Oxepino[2,3‐c]pyrazole Motif via Sulfur Ylide‐mediated Annulation or Me2S involved One‐pot Reaction

Construction of CF3‐containing Oxepino[2,3‐c]pyrazole Motif via Sulfur Ylide‐mediated Annulation... Base promoted [4+3] annulation of trifluoromethylpyrazole(TFPZ) derived α,β‐unsaturated ketones with crotonate‐derived sulfur ylides provided a diverse set of CF3‐containing oxepino[2,3‐c]pyrazole motif in good to excellent yields through a simple, mild and fast manner. Significantly, one‐pot strategy could be successfully applied to this transformation from available materials. Also, the utility of our versatile protocol was further demonstrated by gram‐scale reaction and useful derivation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

Construction of CF3‐containing Oxepino[2,3‐c]pyrazole Motif via Sulfur Ylide‐mediated Annulation or Me2S involved One‐pot Reaction

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References (56)

Publisher
Wiley
Copyright
© 2021 Wiley‐VCH GmbH
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.202100494
Publisher site
See Article on Publisher Site

Abstract

Base promoted [4+3] annulation of trifluoromethylpyrazole(TFPZ) derived α,β‐unsaturated ketones with crotonate‐derived sulfur ylides provided a diverse set of CF3‐containing oxepino[2,3‐c]pyrazole motif in good to excellent yields through a simple, mild and fast manner. Significantly, one‐pot strategy could be successfully applied to this transformation from available materials. Also, the utility of our versatile protocol was further demonstrated by gram‐scale reaction and useful derivation.

Journal

Asian Journal of Organic ChemistryWiley

Published: Nov 1, 2021

Keywords: Trifluoromethylpyrazole; C3 synthons; Sulfur ylide; TFPZ-fused derivatives; one-pot strategy

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