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Base promoted [4+3] annulation of trifluoromethylpyrazole(TFPZ) derived α,β‐unsaturated ketones with crotonate‐derived sulfur ylides provided a diverse set of CF3‐containing oxepino[2,3‐c]pyrazole motif in good to excellent yields through a simple, mild and fast manner. Significantly, one‐pot strategy could be successfully applied to this transformation from available materials. Also, the utility of our versatile protocol was further demonstrated by gram‐scale reaction and useful derivation.
Asian Journal of Organic Chemistry – Wiley
Published: Nov 1, 2021
Keywords: Trifluoromethylpyrazole; C3 synthons; Sulfur ylide; TFPZ-fused derivatives; one-pot strategy
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