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D. Mastellos, Despina Yancopoulou, P. Kokkinos, M. Huber-Lang, G. Hajishengallis, A. Biglarnia, F. Lupu, B. Nilsson, A. Risitano, Daniel Ricklin, John Lambris (2015)
Compstatin: a C3‐targeted complement inhibitor reaching its prime for bedside interventionEuropean Journal of Clinical Investigation, 45
A. Risitano, Daniel Ricklin, Yijun Huang, E. Reis, Hui Chen, P. Ricci, Zhuoer Lin, Caterina Pascariello, M. Raia, M. Sica, L. Vecchio, F. Pane, F. Lupu, R. Notaro, R. Resuello, R. DeAngelis, John Lambris (2014)
Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria.Blood, 123 13
B. Petersen, W. Ramackers, A. Tiede, A. Lucas-Hahn, D. Herrmann, B. Barg‐Kues, Wolfgang Schuettler, L. Friedrich, R. Schwinzer, M. Winkler, H. Niemann (2009)
Pigs transgenic for human thrombomodulin have elevated production of activated protein CXenotransplantation, 16
G. Byrne, C. McGregor (2012)
Cardiac xenotransplantation: progress and challengesCurrent Opinion in Organ Transplantation, 17
J. Abicht, T. Mayr, B. Reichart, S. Buchholz, F. Werner, I. Lutzmann, M. Schmoeckel, A. Bauer, M. Thormann, M. Langenmayer, N. Herbach, H. Pohla, Rudolf Herzog, C. McGregor, D. Ayares, E. Wolf, N. Klymiuk, A. Baehr, A. Kind, C. Hagl, U. Ganswindt, C. Belka, S. Guethoff, P. Brenner (2015)
Pre‐clinical heterotopic intrathoracic heart xenotransplantation: a possibly useful clinical techniqueXenotransplantation, 22
(2015)
: a possibly useful clinical technique
Preclinical heterotopic intratho - racic heart
P. Cowan, A. D'apice (2009)
Complement activation and coagulation in xenotransplantationImmunology and Cell Biology, 87
S. Miyagawa, H. Hirose, R. Shirakura, Yoshihumi Naka, S. Nakata, Y. Kawashima, T. Seya, M. Matsumoto, A. Uenaka, H. Kitamura (1988)
THE MECHANISM OF DISCORDANT XENOGRAFT REJECTIONTransplantation, 46
C. Vogel, D. Fritzinger, Brian Hew, M. Thorne, Holger Bammert (2004)
Recombinant cobra venom factor.Molecular immunology, 41 2-3
B. Nilsson, K. Ekdahl, T. Mollnes, John Lambris (2007)
The role of complement in biomaterial-induced inflammation.Molecular immunology, 44 1-3
KN Ekdahl, Y Teramura, S Asif (2015)
Immune Responses to Biosurfaces
(1998)
Orthotopic heart transplantation in a transgenic pig- to primate model. Transplantation
(1998)
Orthotopic heart transplantation in a transgenic pigtoprimate model
R. Silasi-Mansat, Hua Zhu, N. Popescu, G. Peer, G. Sfyroera, P. Magotti, L. Ivanciu, C. Lupu, T. Mollnes, F. Taylor, G. Kinasewitz, John Lambris, F. Lupu (2010)
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis.Blood, 116 6
P. Brenner, M. Schmoeckel, H. Reichenspurner, C. Wimmer, V. Eder, A. Rucker, T. Felbinger, S. Uchita, M. Hinz, U. Brandl, B. Meiser, C. Hammer, B. Reichart (2004)
MEAN XENOGRAFT SURVIVAL OF 14,6 DAYS IN A SMALL GROUP OF HDAF-TRANSGENIC PIG HEARTS TRANSPLANTED ORTHOTOPICALLY INTO BABOONSTransplantation, 78
John Atkinson, T. Farries (1987)
Separation of self from non-self in the complement system.Immunology today, 8 7-8
Hongchang Qu, Daniel Ricklin, Hongjun Bai, Hui Chen, E. Reis, M. Maciejewski, Apostolia Tzekou, R. DeAngelis, R. Resuello, F. Lupu, P. Barlow, John Lambris (2013)
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties.Immunobiology, 218 4
(2017)
Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood
A. Fiane, T. Mollnes, V. Videm, T. Hovig, K. Høgåsen, O. Mellbye, L. Spruce, W. Moore, A. Sahu, John Lambris (1999)
Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenograftsXenotransplantation, 6
R. Kelly, B. Höchsmann, J. Szer, A. Kulasekararaj, S. Guibert, A. Röth, I. Weitz, E. Armstrong, A. Risitano, C. Patriquin, L. Terriou, P. Muus, A. Hill, M. Turner, H. Schrezenmeier, R. Latour (2015)
Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria.The New England journal of medicine, 373 11
R. Pierson, A. Dorling, D. Ayares, M. Rees, J. Seebach, J. Fishman, B. Hering, D. Cooper (2009)
Current status of xenotransplantation and prospects for clinical applicationXenotransplantation, 16
A. Sahu, B. Kay, John Lambris (1996)
Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library.Journal of immunology, 157 2
A. Wuensch, A. Baehr, A. Bongoni, E. Kemter, A. Blutke, W. Baars, Sonja Haertle, V. Zakhartchenko, M. Kurome, B. Kessler, C. Faber, J. Abicht, B. Reichart, R. Wanke, R. Schwinzer, H. Nagashima, R. Rieben, D. Ayares, E. Wolf, N. Klymiuk (2014)
Regulatory Sequences of the Porcine THBD Gene Facilitate Endothelial-Specific Expression of Bioactive Human Thrombomodulin in Single- and Multitransgenic PigsTransplantation Journal, 97
C. Vial, Daniel Ostlie, Farah Bhatti, Emanuele Cozzi, Martin Goddard, G. Chavez, J. Wallwork, David White, John Dunning (2000)
Life supporting function for over one month of a transgenic porcine heart in a baboon.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 19 2
M. Hölscher, Groenewoud Af (1991)
Current status of the HTK solution of Bretschneider in organ preservation.Transplantation proceedings, 23 5
R. Calne (1970)
Organ transplantation between widely disparate species.Transplantation proceedings, 2 4
Thomas Thomas, S. Rollins, R. Rother, Michelle Giannoni, Sandra Hartman, E. Elliott, S. Nye, L. Matis, S. Squinto, M. Evans (1996)
Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv.Molecular immunology, 33 17-18
E. Reis, R. DeAngelis, Hui Chen, R. Resuello, Daniel Ricklin, John Lambris (2015)
Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters.Immunobiology, 220 4
I. Kourtzelis, Anaisa Ferreira, Ioannis Mitroulis, Daniel Ricklin, Stefan Bornstein, Claudia Waskow, John Lambris, T. Chavakis (2014)
Complement Inhibition in a Xenogeneic Model of Interactions Between Human Whole Blood and Porcine EndotheliumHormone and Metabolic Research, 47
B. Ekser, M. Ezzelarab, H. Hara, D. Windt, M. Wijkstrom, R. Bottino, M. Trucco, DavidA. Cooper (2012)
Clinical xenotransplantation: the next medical revolution?The Lancet, 379
D. Cooper, A. Keogh, J. Brink, P. Corris, W. Klepetko, R. Pierson, M. Schmoeckel, R. Shirakura, L. Stevenson (2000)
Report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation: the present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 19 12
Daniel Ricklin, John Lambris (2008)
Compstatin: a complement inhibitor on its way to clinical application.Advances in experimental medicine and biology, 632
U. Brandl, S. Michel, M. Erhardt, P. Brenner, I. Bittmann, M. Rössle, H. Baschnegger, A. Bauer, C. Hammer, M. Schmoeckel, B. Reichart (2005)
Administration of GAS914 in an orthotopic pig‐to‐baboon heart transplantation modelXenotransplantation, 12
M. Schmoeckel, Farah Bhatti, A. Zaidi, E. Cozzi, P. Waterworth, M. Tolan, G. Pino-Chavez, Martin Goddard, R. Warner, G. Langford, John Dunning, J. Wallwork, David White (1998)
Orthotopic heart transplantation in a transgenic pig-to-primate model.Transplantation, 65 12
Daniel Ricklin, G. Hajishengallis, Kun Yang, John Lambris (2010)
Complement: a key system for immune surveillance and homeostasisNature Immunology, 11
A. Sörman, Lu Zhang, Z. Ding, B. Heyman (2014)
How antibodies use complement to regulate antibody responses.Molecular immunology, 61 2
H. Bretschneider, G. Hübner, D. Knoll, B. Lohr, H. Nordbeck, P. Spieckermann (1975)
Myocardial resistance and tolerance to ischemia: physiological and biochemical basis.The Journal of cardiovascular surgery, 16 3
(2005)
Administration of GAS 914 in an orthotopic pigtobaboon heart transplantation model
K. Ekdahl, Y. Teramura, S. Asif, N. Jonsson, P. Magnusson, B. Nilsson (2015)
Thromboinflammation in Therapeutic Medicine.Advances in experimental medicine and biology, 865
M. Mohiuddin, Avneesh Singh, P. Corcoran, R. Hoyt, Marvin Thomas, D. Ayares, K. Horvath (2014)
Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation.The Journal of thoracic and cardiovascular surgery, 148 3
M. Mohiuddin, Avneesh Singh, P. Corcoran, Robert Hoyt, M. Thomas, B. Lewis, Michael Eckhaus, Keith Reimann, N. Klymiuk, Eckhard Wolf, D. Ayares, Keith Horvath (2014)
One‐Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon ModelAmerican Journal of Transplantation, 14
G. Byrne, C. McGregor, M. Breimer (2015)
Recent investigations into pig antigen and anti-pig antibody expression.International journal of surgery, 23 Pt B
Maximilian University, Munich, Germany Background: The complement system plays a crucial role in acute xenogeneic reactions Department of Clinical Pathobiochemistry, Medical after cardiac transplantation. We used an ex vivo perfusion model to investigate the Faculty, Technische Universität Dresden, effect of Cp40, a compstatin analog and potent inhibitor of complement at the level of C3. Dresden, Germany Walter-Brendel-Centre, Ludwig Maximilian Methods: Fifteen wild- type pig hearts were explanted, cardiopleged, and reperfused University, Munich, Germany ex vivo after 150 minutes of cold ischemia. Hearts were challenged in a biventricular Department of Pathology and Laboratory working heart mode to evaluate cardiac perfusion and function. In the treatment Medicine, University of Pennsylvania, Pennsylvania, PA, USA group (n=5), the complement cascade was blocked at the level of C3 using Cp40, using Institute of Laboratory Medicine of Ludwig diluted human blood. Untreated human and porcine blood was used for controls. Maximilian University, Munich, Germany Results: Throughout the perfusion, C3 activation was inhibited when Cp40 was used Chair of Livestock Biotechnology, School (mean of all time points: 1.11 ± 0.34% vs 3.12 ± 0.48% control activation; P<.01). of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany Compared to xenoperfused controls, the cardiac index improved significantly
Xenotransplantation – Wiley
Published: Jan 1, 2017
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