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C. Li (1978)
On measuring genetic distance by selection intensity.Annals of human genetics, 41 4
Comments on C. C. Liâs paper on measuring genetic distance BY CEDRIC A. B. SMITH Galton Laboratory, University College London Li defines a measure d,, of genetic distance between populations 1 and 2 by Two comments about this seem appropriate. I n the first place it is not really symmetrical (as Li states) but antisymmetrical; that is, d,, = - a,,. To get a symmetrical measure we would have t o take d:,. Secondly, suppose the two populations differ only a little, so that we can write P =p+4 I 2 =p-& % q1= Q2 q-8, =4+& where p = Q(pl+p2), = $(q1+q2); q and S is small. Then (if we interpret âlogâ t o mean natural logarithm) the formula reduces to dl2 2: - 26/PP, neglecting terms in J2,or in other words, d;, N 4S2/p2q2. This is clearly appreciably different from most of the usual forms of âgenetic distanceâ which would equal S2/pq, or some simple multiple of this for small 6. But the two forms will not differ very much in order of magnitude (unless either p or q are near zero). Unfortunately this form suggests no very obvious generalization t o more than two populations. REFERENCE LI,C. C. (1978). On measuring genetic distance by selection intensity. Ann. Hum. Genet., Lond. 41, 501-4.
Annals of Human Genetics – Wiley
Published: May 1, 1978
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