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Column chromatography of human red cell acid phosphatase

Column chromatography of human red cell acid phosphatase BY D. A. HOPKINSON AND HARRY HARRIS Medical Research Council Human Biochemical Genetics Research Unit, The Galton Laboratory, University College London, Cower Street, London, W.C. 1 The polymorphism of human red cell acid phosphatase which can be detected by starch-gel electrophoresis is genetically determined. Nine distinct phenotypes have been described (Hopkinson, Spencer & Harris, 1963; Lai, Nevo & Steinberg, 1964; Giblett & Scott, 1965; Karp & Sutton, 1967) and these are referred to as A, BA, B, CA, CB, C, RA, RB, and DB. Family studies indicate that phenotypes A, B, and C are produced by the homozygous genoPbPb and P "respectively, and phenotypes BA, CA and CB represent heteroP types Papa, PaPC P b Prespectively, where Pa, and Pc are three alleles at an and Pb zygous genotypes PUPb, autosomal locus. Similarly the rare phenotypes RA, RB and DB are thought to represent heterozygous combinations of the common alleles Pa or Pb with rare alleles Pr or Pa. In each of the nine phenotypes which have been identified at least two components with redcell acid phosphatase activity can be detected after starch-gel electrophoresis. Moreover in each of the three postulated homozygotes A, B and C there are http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Column chromatography of human red cell acid phosphatase

HOPKINSON, D. A.; HARRIS, HARRY
Annals of Human Genetics , Volume 31 (1) – Aug 1, 1967
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References (20)

Publisher
Wiley
Copyright
Copyright © 1967 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1967.tb01251.x
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Abstract

BY D. A. HOPKINSON AND HARRY HARRIS Medical Research Council Human Biochemical Genetics Research Unit, The Galton Laboratory, University College London, Cower Street, London, W.C. 1 The polymorphism of human red cell acid phosphatase which can be detected by starch-gel electrophoresis is genetically determined. Nine distinct phenotypes have been described (Hopkinson, Spencer & Harris, 1963; Lai, Nevo & Steinberg, 1964; Giblett & Scott, 1965; Karp & Sutton, 1967) and these are referred to as A, BA, B, CA, CB, C, RA, RB, and DB. Family studies indicate that phenotypes A, B, and C are produced by the homozygous genoPbPb and P "respectively, and phenotypes BA, CA and CB represent heteroP types Papa, PaPC P b Prespectively, where Pa, and Pc are three alleles at an and Pb zygous genotypes PUPb, autosomal locus. Similarly the rare phenotypes RA, RB and DB are thought to represent heterozygous combinations of the common alleles Pa or Pb with rare alleles Pr or Pa. In each of the nine phenotypes which have been identified at least two components with redcell acid phosphatase activity can be detected after starch-gel electrophoresis. Moreover in each of the three postulated homozygotes A, B and C there are

Journal

Annals of Human Genetics – Wiley

Published: Aug 1, 1967

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