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Coeliac disease: follow‐up linkage study provides further support for existence of a susceptibility locus on chromosome 11p11

Coeliac disease: follow‐up linkage study provides further support for existence of a... Susceptibility to coeliac disease has a strong genetic component. The HLA associations have been well described but it is clear that other genes outside this region must also be involved in disease development. Two previous genome‐wide linkage studies using the affected sib pair method produced conflicting results. Our own family based linkage study of 16 highly informative pedigrees identified 17 possibly linked regions, each of which produced a result significant at p < 0.05 or less. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Coeliac disease: follow‐up linkage study provides further support for existence of a susceptibility locus on chromosome 11p11

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References (37)

Publisher
Wiley
Copyright
Copyright © 2001 Wiley Subscription Services
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1046/j.1469-1809.2001.6540377.x
Publisher site
See Article on Publisher Site

Abstract

Susceptibility to coeliac disease has a strong genetic component. The HLA associations have been well described but it is clear that other genes outside this region must also be involved in disease development. Two previous genome‐wide linkage studies using the affected sib pair method produced conflicting results. Our own family based linkage study of 16 highly informative pedigrees identified 17 possibly linked regions, each of which produced a result significant at p < 0.05 or less.

Journal

Annals of Human GeneticsWiley

Published: Jan 1, 2001

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