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References (35)
-
Z. Khalpey, A. Yuen, K. Kalsi, Z. Kochan, J. Karbowska, E. Slominska, M. Forni, M. Macherini, M. Bacci, P. Batten, M. Lavitrano, M. Yacoub, R. Smolenski (2005)
Loss of ecto-5'nucleotidase from porcine endothelial cells after exposure to human blood: Implications for xenotransplantation.Biochimica et biophysica acta, 1741 1-2
-
A. Ghanekar, M. Mendicino, Hao Liu, Wei He, Mingfeng Liu, R. Zhong, M. Phillips, G. Levy, D. Grant (2004)
Endothelial Induction of fgl2 Contributes to Thrombosis during Acute Vascular Xenograft Rejection1The Journal of Immunology, 172
-
K. Dwyer, T. Mysore, Sandra Crikis, S. Robson, H. Nandurkar, P. Cowan, A. D'apice (2006)
The transgenic expression of human CD39 on murine islets inhibits clotting of human blood.Transplantation, 82 3
-
S. Robson, E. Kaczmarek, J. Siegel, D. Candinas, K. Koziak, M. Millan, W. Hancock, F. Bach (1997)
Loss of ATP Diphosphohydrolase Activity with Endothelial Cell ActivationThe Journal of Experimental Medicine, 185
-
C. Esmon (2000)
The protein C pathwayCritical Care Medicine, 28
-
C. Kopp, S. Robson, J. Siegel, J. Anrather, H. Winkler, S. Grey, E. Kaczmarek, F. Bach, C. Geczy (1998)
Regulation of Monocyte Tissue Factor Activity by Allogeneic and Xenogeneic Endothelial CellsThrombosis and Haemostasis, 79
-
Y. Tseng, K. Kuwaki, F. Dor, A. Shimizu, S. Houser, Y. Hisashi, Kazuhiko Yamada, S. Robson, M. Awwad, H. Schuurman, D. Sachs, D. Cooper (2005)
α1,3-Galactosyltransferase Gene-Knockout Pig Heart Transplantation in Baboons with Survival Approaching 6 MonthsTransplantation, 80
-
M. Mendicino, Mingfeng Liu, A. Ghanekar, Wei He, C. Koscik, I. Shalev, M. Javadi, J. Turnbull, Wenhao Chen, L. Fung, S. Sakamoto, P. Marsden, Thomas Waddell, M. Phillips, R. Gorczynski, Gary Levy, D. Grant (2005)
Targeted Deletion of Fgl-2/Fibroleukin in the Donor Modulates Immunologic Response and Acute Vascular Rejection in Cardiac XenograftsCirculation, 112
-
C. Kopp, Jonathan Siegel, W. Hancock, J. Anrather, H. Winkler, C. Geczy, E. Kaczmarek, F. Bach, S. Robson (1997)
Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors.Transplantation, 63 5
-
W. Ird (2005)
Spatial and temporal dynamics of the endothelium -
O. Piro, G. Broze (2005)
Comparison of cell‐surface TFPIα and βJournal of Thrombosis and Haemostasis, 3
-
A. Billiau, Yuan Lin, L. Moons, M. Dewerchin, M. Waer, P. Carmeliet (2005)
Role of growth arrest specific gene 6 in immune and non-immune aspects of vascular lesions occurring during delayed xenograft rejectionXenotransplantation, 12
-
Pike Pike, Buckle Buckle, Le Bonniec Le Bonniec, Church Church (2005)
Control of the coagulation system by serpins. Getting by with a little help from glycosaminoglycansFEBS J, 272
-
K. Dwyer, S. Robson, H. Nandurkar, D. Campbell, H. Gock, L. Murray-Segal, N. Fisicaro, T. Mysore, E. Kaczmarek, P. Cowan, A. D'apice (2004)
Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.The Journal of clinical investigation, 113 10
-
(2001)
by human soluble urinary thrombomod - ulin in the xeno - perfused porcine liver -
S. Maroney, A. Cunningham, Josephine Ferrel, R. Hu, S. Haberichter, C. Mansbach, R. Brodsky, D. Dietzen, A. Mast (2006)
A GPI‐anchored co‐receptor for tissue factor pathway inhibitor controls its intracellular trafficking and cell surface expressionJournal of Thrombosis and Haemostasis, 4
-
E. Cozzi, P. Simioni, M. Boldrin, M. Seveso, F. Calabrese, N. Baldan, R. Busetto, D. Tormene, S. Gavasso, M. Castagnaro, Y. Echelard, Tim Rice, M. Plebani, P. Carraro, E. Bosio, M. Valente, A. Pagnan, G. Thiene, E. Ancona (2005)
Effects of Long-term Administration of High-dose Recombinant Human Antithrombin in Immunosuppressed Primate Recipients of Porcine XenograftsTransplantation, 80
-
Jing Zhang, O. Piro, Lan Lu, G. Broze (2003)
Glycosyl Phosphatidylinositol Anchorage of Tissue Factor Pathway InhibitorCirculation: Journal of the American Heart Association, 108
-
B. Lwaleed, P. Bass (2006)
Tissue factor pathway inhibitor: structure, biology and involvement in diseaseThe Journal of Pathology, 208
-
R. Pike, A. Buckle, B. Bonniec, F. Church (2005)
Control of the coagulation system by serpinsThe FEBS Journal, 272
-
K. Kuwaki, C. Knosalla, F. Dor, B. Gollackner, Y. Tseng, S. Houser, N. Mueller, D. Prabharasuth, A. Alt, K. Moran, Jane Cheng, A. Behdad, D. Sachs, J. Fishman, H. Schuurman, M. Awwad, D. Cooper (2004)
Suppression of Natural and Elicited Antibodies in Pig‐to‐Baboon Heart Transplantation Using a Human Anti‐Human CD154 mAb‐Based RegimenAmerican Journal of Transplantation, 4
-
(2006)
A GPIanchored co-receptor for tissue factor pathway inhibitor controls its intracellular trafficking and cell surface expression -
(2005)
Characterization of pig thrombomodulin and its interaction with the human protein C anticoagulant pathway -
Endothelial cell protection in xeno - -
C. Kopp, Shane T. Grey, Jonathan Siegel, A. Mcshea, H. Vetr, C. Wrighton, J. Esch, F. Bach, S. Robson (1998)
Expression of human thrombomodulin cofactor activity in porcine endothelial cells.Transplantation, 66 2
-
Da-xin Chen, Michèle Weber, J. McVey, G. Kemball-Cook, E. Tuddenham, R. Lechler, A. Dorling (2004)
Complete Inhibition of Acute Humoral Rejection Using Regulated Expression of Membrane‐tethered Anticoagulants on Xenograft EndotheliumAmerican Journal of Transplantation, 4
-
Charles Glaser, John Morser, J. Clarke, E. Blasko, Kirk Mclean, Irene Kuhn, I. Chang, Jiing‐Huey Lin, L. Vilander, William Andrews, David Light (1992)
Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation.The Journal of clinical investigation, 90 6
-
P. Cowan, A. Aminian, H. Barlow, A. Brown, K. Dwyer, Robin Filshie, N. Fisicaro, David Francis, H. Gock, David Goodman, J. Katsoulis, S. Robson, E. Salvaris, T. Shinkel, A. Stewart, A. D'apice (2002)
Protective Effects of Recombinant Human Antithrombin III in Pig‐to‐Primate Renal XenotransplantationAmerican Journal of Transplantation, 2
-
O. Piro, G. Broze (2004)
Role for the Kunitz-3 Domain of Tissue Factor Pathway Inhibitor-&agr; in Cell Surface BindingCirculation, 110
-
Jonathan Siegel, Shane T. Grey, B. Lesnikoski, Christoph Kopp, Miguel Soares, J. Esch, Fritz Bach, Simon Robson (1997)
Xenogeneic endothelial cells activate human prothrombin.Transplantation, 64 6
-
M. Shiraishi, T. Oshiro, K. Taira, E. Nozato, M. Nagahama, H. Nomura, Y. Takushi, H. Sugawa, Y. Muto (2001)
IMPROVED HEPATIC MICROCIRCULATION BY HUMAN SOLUBLE URINARY THROMBOMODULIN IN THE XENO-PERFUSED PORCINE LIVERTransplantation, 71
-
Jeffrey Lawson, L. Daniels, J. Platt (1997)
The evaluation of thrombomodulin activity in porcine to human xenotransplantation.Transplantation proceedings, 29 1-2
-
G. Byrne, J. Schirmer, D. Fass, S. Teotia, W. Kremers, Hui Xu, B. Naziruddin, H. Tazelaar, J. Logan, C. McGregor (2005)
Warfarin or Low‐Molecular‐Weight Heparin Therapy does not Prolong Pig‐To‐Primate Cardiac Xenograft FunctionAmerican Journal of Transplantation, 5
-
Y. Banz, R. Rieben (2006)
Endothelial cell protection in xenotransplantation: looking after a key player in rejectionXenotransplantation, 13
-
Da-xin Chen, A. Dorling (2005)
Microcoagulation processes after xenotransplantationCurrent Opinion in Organ Transplantation, 10
- Publisher
- Wiley
- Copyright
- Copyright © 2007 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0908-665X
- eISSN
- 1399-3089
- DOI
- 10.1111/j.1399-3089.2006.00368.x
- pmid
- 17214700
- Publisher site
- See Article on Publisher Site
Abstract
Abstract: Acute humoral rejection remains the major barrier to long‐term pig‐to‐primate xenograft survival, and microvascular thrombosis is a critical element of the rejection process. It appears that persistent endothelial cell activation and injury, by even low levels of anti‐graft antibodies, eventually overwhelm the cellular anticoagulant defences and promote the development of thrombotic microangiopathy. Porcine endothelium may be particularly vulnerable because of cross‐species molecular incompatibilities affecting the function of thrombomodulin and possibly TFPI. Recent data from small animal models suggest that transgenic overexpression of anti‐thrombotic molecules on xenograft endothelium is capable of inhibiting intravascular thrombosis and preventing acute humoral rejection. In conjunction with existing genetic modifications (e.g. Gal KO, hDAF), this is a promising strategy to move xenotransplantation to the clinic.
Journal
Xenotransplantation – Wiley
Published: Jan 1, 2007