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Clozapine–induced Pericarditis

Clozapine–induced Pericarditis Clozapine‐induced pericarditis is rare. It can present with variable symptoms from pleuritic chest pain (as part of a generalised polyserositic process) to cardiac tamponade. In the majority of documented cases, symptoms have completely resolved with the discontinuation of clozapine ( Layland et al., 2009 ). We report a 32 year old male with resistant schizophrenia who developed pericarditis at the 5 th week of clozapine. The patient had previously responded poorly to a number of antipsychotic medications, and had attempted self harm several times in the context of his delusional beliefs. Finally, his treating team decided to commence clozapine. Pre clozapine investigations were normal, with no past/family history of cardiac disease. The dose of clozapine was titrated gradually and the patient was discharged from the psychiatric unit at the 4 th week with a dose of 350 mg clozapine daily. Troponin I and ECG were normal in the first 4 weeks. At the 5 th week FBE was normal, however the ECG revealed diffuse saddle shaped (concave) ST segment elevation with PR segment depression, so the patient was rushed to the Emergency Department. He complained of left sided pleuritic chest pain associated with shortness of breath. Physical examination http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asia-Pacific Psychiatry Wiley

Clozapine–induced Pericarditis

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References (5)

  • H. Meltzer, L. Alphs, A. Green, A. Altamura, R. Anand, A. Bertoldi, M. Bourgeois, G. Chouinard, M. Islam, J. Kane, R. Krishnan, J. Lindenmayer, S. Potkin, Saide Altinsan, Siemion Altman, Likiana Avigo, R. Balon, Vanda Benesová, Luis Bengochea, I. Bitter, Elisabeth Bokowska, B. Carpiniello, D. Casey, G. Cassano, J. Chou, L. Chvila, J. Daléry, P. Delgado, L. Dell’Osso, C. Eisdorfer, R. Emsley, D. Eng, Tom Fahy, V. Folnegovic, S. Frangou, P. Gargoloff, A. Giannelli, I. Glick, Richard Greenberg, G. Grossberg, D. Gundersen, Hannale Heila, G. Hsu, N. Iqbal, M. Jakovljevič, R. Josiassen, Akos Kassaifarkas, R. Kerwin, F. Khidichian, M. Knesevich, J. Krasuski, Vinod Kumar, V. Larach, M. Lesem, Shôn Lewis, P. Llorca, H. Logue, Stephen Martin, Muriel Maurel-Raymondet, L. Mód, Eva Morik, C. Morra, A. Mortimer, M. Noursalehi, G. Ostorharics-Horvath, I. Paclt, Jörg-Peter Pahl, L. Pestreich, J. Peters, Rosario Pioli, Michael Plopper, T. Posever, M. Rapaport, D. Robinson, C. Robotti, Harry Rohme, F. Rouillon, D. Sack, Isaac Sakinsofsky, Phillip Seibel, G. Simpson, N. Temkin, O. Tomori, Santha Vaidain, Zdeòka Vyhnándová, F. Young, D. Zimbroff, M. Zimmerman (2003)

    Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT).

    Archives of general psychiatry, 60 1

  • Layland (2009)

    Clozapine induced cardiotoxicity

    a clinical update, 190

  • Meltzer (2003)

    Clozapine treatment for suicidality in schizophrenia

    International Suicide Prevention Trial (InterSePT), 60

  • Aida Murko, S. Clarke, D. Black (2002)

    Clozapine and pericarditis with pericardial effusion.

    The American journal of psychiatry, 159 3

  • (2009)

    Clinical Update

Publisher
Wiley
Copyright
Copyright © 2010 Blackwell Publishing Asia Pty Ltd
ISSN
1758-5864
eISSN
1758-5872
DOI
10.1111/j.1758-5872.2010.00102.x
Publisher site
See Article on Publisher Site

Abstract

Clozapine‐induced pericarditis is rare. It can present with variable symptoms from pleuritic chest pain (as part of a generalised polyserositic process) to cardiac tamponade. In the majority of documented cases, symptoms have completely resolved with the discontinuation of clozapine ( Layland et al., 2009 ). We report a 32 year old male with resistant schizophrenia who developed pericarditis at the 5 th week of clozapine. The patient had previously responded poorly to a number of antipsychotic medications, and had attempted self harm several times in the context of his delusional beliefs. Finally, his treating team decided to commence clozapine. Pre clozapine investigations were normal, with no past/family history of cardiac disease. The dose of clozapine was titrated gradually and the patient was discharged from the psychiatric unit at the 4 th week with a dose of 350 mg clozapine daily. Troponin I and ECG were normal in the first 4 weeks. At the 5 th week FBE was normal, however the ECG revealed diffuse saddle shaped (concave) ST segment elevation with PR segment depression, so the patient was rushed to the Emergency Department. He complained of left sided pleuritic chest pain associated with shortness of breath. Physical examination

Journal

Asia-Pacific Psychiatry – Wiley

Published: Dec 1, 2010

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