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Ilana Goldberg-Cohen, Henry Furneauxb, A. Levy (2002)
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Adenylate/uridylate‐rich elements (AREs), which are found in the 3′‐untranslated region (UTR) of many mRNAs, influence the stability of cytoplasmic mRNA. HuR (human antigen R) binds to AREs and regulates various genes. In order to reveal the RNA‐recognition mechanism of HuR protein, an RNA‐binding region of human HuR containing two N‐terminal RNA‐recognition motif domains bound to an 11‐base RNA fragment has been crystallized. The crystals belonged to space group P212121, with unit‐cell parameters a = 42.4, b = 44.9, c = 91.1 Å. X‐ray diffraction data were collected to 1.8 Å resolution.
Acta Crystallographica Section F – Wiley
Published: Mar 1, 2009
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