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(1976)
Cytogenetic investi - STERN , C . ( 1936 ) . Somatic crossing over and segregation in D . melanogaster
C. Stern (1969)
Gene expression in genetic mosaics.Genetics, 61 1
Lehmann Lehmann, Kirk‐Bell Kirk‐Bell, Arlett Arlett, Patterson Patterson, Lo‐ Lo‐, Weerd‐Kastel Weerd‐Kastel, De De, Bootsma Bootsma (1975)
Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV‐irradiationProc. Natn. Ad. Sci. U.S.A., 72
R. Chaganti, S. Schonberg, J. German (1974)
A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.Proceedings of the National Academy of Sciences of the United States of America, 71 11
H. Kato (1974)
Spontaneous sister chromatid exchanges detected by a BUdR-labelling methodNature, 251
K. Kraemer, H. Coon, R. Petinga, S. Barrett, A. Rahe, J. Robbins (1975)
Genetic heterogeneity in xeroderma pigmentosum: complementation groups and their relationship to DNA repair rates.Proceedings of the National Academy of Sciences of the United States of America, 72 1
Kraemer Kraemer, Coon Coon, Petinga Petinga, Barrett Barrett, Rahe Rahe, Robbins Robbins (1976)
Genetic heterogeneity in xeroderma pigmentosum: complementation groups and their relationship to DNA repair rateProc. Natn. Acud. Sci. U.S.A., 72
R. Hand, J. German (1975)
A retarded rate of DNA chain growth in Bloom's syndrome.Proceedings of the National Academy of Sciences of the United States of America, 72 2
B. Sutherland, M. Rice, E. Wagner (1975)
Xeroderma pigmentosum cells contain low levels of photoreactivating enzyme.Proceedings of the National Academy of Sciences of the United States of America, 72 1
S. Latt (1973)
Microfluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes.Proceedings of the National Academy of Sciences of the United States of America, 70 12
(1974)
Bloom ’ s syndrome 11 . The prototype of human genetic disorders predisposing to chromosome instability and cancer
Weaver Weaver (1960)
Somatic crossing over and its genetic control iDrosophila. Genetics, 45
Henderson Henderson (1962)
Temperature and chiasma formation in Schistocea gregoriaChromosoma (Bed.), 13
Dutrillaux Dutrillaux, Fosse Fosse, Prieur Prieur, Lejeune Lejeune (1974)
Analyse des Bchanges de chromatides dans les cellules somatiques humainesChromoaoma:(Bed.), 48
Keutel Keutel (1969)
Cytogenetische, immunologsche und cytologische Familienuntersuchungen bei Bloom‐SyndromHumangenetik, 8
P. Perry, H. Evans (1975)
Cytological detection of mutagen–carcinogen exposure by sister chromatid exchangeNature, 258
Latt Latt (1973)
Miorofluorometrio detection of deoxyribonuoleic acid replication in human metaphase chromosomesProc. Natn. Ad. Sci. U.S.A., 70
E. Weaver (1960)
Somatic Crossing over and Its Genetic Control in Drosophila.Genetics, 45 3
Passarge Passarge (1972)
Spontaneous chromosomal instabilityHumangenetik, 16
R. Holliday (1964)
THE INDUCTION OF MITOTIC RECOMBINATION BY MITOMYCIN C IN USTILAGO AND SACCHAROMYCES.Genetics, 50
Wolff Wolff, Perry Perry (1974)
Differential Giemsa staining of sister chromatids and the study of sister chromatid exchanges without autoradiographyChromosoma (Berl.), 48
P. Perry, S. Wolff (1974)
New Giemsa method for the differential staining of sister chromatidsNature, 251
J. German (1964)
Cytological Evidence for Crossing-Over in vitro in Human Lymphoid CellsScience, 144
C. Stern (1968)
Genetic Mosaics, And Other Essays
C. Ramsay, T. Coltart, S. Blunt, S. Pawsey, F. Giannelli (1974)
Prenatal diagnosis of xeroderma pigmentosum. Report of the first successful case.Lancet, 2 7889
R. Tice, J. Chaillet, E. Schneider (1975)
Evidence derived from sister chromatid exchanges of restricted rejoining of chromatid subunitsNature, 256
A. Lehmann, S. Kirk-Bell, C. Arlett, M. Paterson, P. Lohman, E. Weerd-Kastelein, D. Bootsma (1975)
Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.Proceedings of the National Academy of Sciences of the United States of America, 72 1
S. Galloway, H. Evans (1975)
Sister chromatid exchange in human chromosomes from normal individuals and patients with ataxia telangiectasia.Cytogenetics and cell genetics, 15 1
Hayashi Hayashi, Schmid Schmid (1975)
The rate of sister chromatid exchanges parallel to spontaneous chromosome breakage in Fanconi anemia and to Trenimon‐induced aberration in human lymphocytes and fibroblastsHumangenetik, 29
Stern Stern (1936)
Somatic crossing over and segregation in D. melanogasterGenetics, 21
S. Wolff, P. Perry (1975)
Insights on chromosome structure from sister chromatid exchange ratios and the lack of both isolabelling and heterolabelling as determined by the FPG technique.Experimental cell research, 93 1
Cleaver Cleaver, Bootsma Bootsma, Friedberg Friedberg (1975)
Human diseases with genetically altered DNA repair processesGenetics, 79
C. Tokunaga, N. Arnheim (1966)
Age dependence of the locations of x-ray induced somatic crossing over in Drosophila.Genetics, 54 1
Sperling Sperling, Wegner R.‐D. Riehm Wegner R.‐D. Riehm, Obe Obe (1976)
Frequency and distribution of sister‐chromatid exchanges in a case of Fanconi's anemiaHumangenetik, 27
H. Grüneberg (1966)
The case for somatic crossing over in the mouse.Genetical research, 7 1
Sperling Sperling, Goll Goll, Kunze Kunze, Ludtke Ludtke, Tolksdorf Tolksdorf, Obe Obe (1976)
Cytogenetic investigations in a new case of Bloom's syndromeHumangenetik, 31
Sutherland Sutherland, Rioe Rioe, Wagner Wagner (1976)
Xeroderma pigmentosum cells contain low levels of photoreactivating enzymeProc. Natn. Ad. Sci. U.S.A., 72
exchanges in a case of Fanconi's anemia. Humangenetik 27, 227-30. gations in a new case of Bloom's syndrome
V. Maher, N. Birch, J. Otto, J. MacCormick (1975)
Cytotoxicity of carcinogenic aromatic amides in normal and xeroderma pigmentosum fibroblasts with different DNA repair capabilities.Journal of the National Cancer Institute, 54 6
BY CLAUS R. BARTRAM, THEA KOSKE-WESTPHAL AND EBERHARD PASSARGE* Institut f u r Humangenetik, Universitat Hamburg Recent techniques to detect sister chromatid exchanges (SCE) in somatic metaphase chromosomes (Latt, 1973; Kato, 1974; Perry & Wolff, 1974; Wolff & Perry, 1974; Dutrillaux et al. 1974; Perry & Evans, 1975) afford an opportunity to examine chromosomal instability occurring in cultured cells of some hereditary disorders. The results of chromatid exchanges can be observed as differences in the uptake of certain stains by the two chromatids of each metaphase chromosome after the cell has replicated twice in the presence of 5-bromodeoxyuridine (BrdU) prior to harvest. This thymidine analogue, when incorporated into DNA, reduces the ultraviolet light fluorescence of fluorochromes such as Hoechst 33258 (Latt, 1973) or acridine orange (Kato, 1974; Perry & Wolff, 1974) bound to poly(da-dT) to about 20% when bound to poly(dA-BrdU). In addition, permanently Giemsa-stained preparations can be obtained following exposure to fluorescent dyes (Perry & Wolff, 1974; Wolff & Perry, 1974). Two cell cycles in the dark (to prevent artificial induction of SCEs by photolysis of BrdU-containing DNA) are required to observe a sharp demarcation between one brightly fluorescent or deeply Giemsa-stained chromatid, and one that is
Annals of Human Genetics – Wiley
Published: Jul 1, 1976
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