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References (13)
-
Y. Sunaga, T. Gonoi, T. Shibasaki, K. Ichikawa, H. Kusama, H. Yano, S. Seino (2001)
The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.European journal of pharmacology, 431 1
-
F. Gasparrini, D. Misiti, C. Villani (2001)
High-performance liquid chromatography chiral stationary phases based on low-molecular-mass selectors.Journal of chromatography. A, 906 1-2
-
A. Goodman‐Gilman, L. Goodman (1985)
The Pharmacological Basis of Therapeutics -
H. Shinkai, M. Nashikawa, Yusuke Sato (1989)
Separation of a New Antidiabetic Agent, N-(Trans-4-Isopropylcyclohexylcarbonyl)-D-Phenylalanine, and its Isomers by Chiral High-Performance Liquid ChromatographyJournal of Liquid Chromatography & Related Technologies, 12
-
Gengliang Yang, Zhiwei Li, Dexian Wang, Zhe-feng Zhang, Er-dong Liu, Yi Chen (2002)
Chiral separation of N-(trans-4-isopropylcyclohexylcarbonyl)-D,L-phenylalanine isomers by high performance liquid chromatographyChromatographia, 56
-
L. Sorbera, P. Leeson, R. Castañer, J. Castaǹer (2000)
Mitiglinide Calcium HydrateDrugs of The Future, 25
-
Lushan Yu, Si-jie Lu, Yongjun Lin, S. Zeng (2007)
Carboxyl-glucuronidation of mitiglinide by human UDP-glucuronosyltransferases.Biochemical pharmacology, 73 11
-
Hideki Ohnota, Takashi Koizumi, N. Tsutsumi, M. Kobayashi, S. Inoue, F. Sato (1994)
Novel rapid- and short-acting hypoglycemic agent, a calcium(2s)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) that acts on the sulfonylurea receptor: comparison of effects between KAD-1229 and gliclazide.The Journal of pharmacology and experimental therapeutics, 269 2
-
Yusuke Sato, M. Nishikawa, H. Shinkai (1989)
Analysis of Enantiomers of a New Antidiabetic Agent in Plasma by High-Performance Liquid ChromatographyJournal of Liquid Chromatography & Related Technologies, 12
-
Lushan Yu, Z. Su (2006)
Determination of mitiglinide in rat plasma by high-performance liquid chromatography with UV detection.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 834 1-2
-
Wenhui Gao, Zhefeng Zhang, Zhiwei Li, G. Liang (2007)
Chiral separation of two pairs of enantiomers of tadalafil by high-performance liquid chromatography.Journal of chromatographic science, 45 8
-
Zhe-feng Zhang, Gengliang Yang, G. Liang, Haiyan Liu, Yi Chen (2004)
Chiral separation of tamsulosin isomers by HPLC using cellulose tris (3,5-dimethhylphenylcarbamate) as a chiral stationary phase.Journal of pharmaceutical and biomedical analysis, 34 3
-
(1992)
FDA Policy Statement for the Development of New Stereoisomeric Drugs
- Publisher
- Wiley
- Copyright
- Copyright © 2009 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 1001-604X
- eISSN
- 1614-7065
- DOI
- 10.1002/cjoc.200990022
- Publisher site
- See Article on Publisher Site
Abstract
A chiral high‐performance liquid chromatographic method was developed for the enantioseparation of a new insulinotropic drug of the glinide class with rapid onset. The chiral separation was performed on a Sumichiral OA‐3300 column (250 mm×4.6 mm, 5 µm) with methanol containing 0.05 mol/L ammonium acetate as the optimized mobile phase at detection wavelengh 210 nm. Baseline separation of the two enantiomers was obtained in 22 min with a resolution of 3.01. Calibration graphs were constructed in a range of 0.028–5.6 µg·mL−1 for S‐ and 0.03–6.0 µg·mL−1 for R‐(−)‐enantiomer, respectively. The linear correlation equations are: y=1.32×103x−2.54 (r=0.9997) for S‐enantiomer and y=1.15×103x−1.78 (r=0.9998) for R‐enantiomer, respectively. The limits of detection obtained by S/N=3 were 0.15 ng for S‐ and 0.10 ng for R‐enantiomer, respectively. RSD of the method was below 1.0% (n=5).
Journal
Chinese Journal of Chemistry – Wiley
Published: Jan 1, 2009
Keywords: ; ; ;