Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/children-with-recurrent-otitis-show-defective-ifn-producing-cells-in-HlwDDUyGf5
References (26)
-
G. Ciprandi, M. Tosca, L. Fasce (2006)
Allergic children have more numerous and severe respiratory infections than non‐allergic childrenPediatric Allergy and Immunology, 17
-
(1998)
Th 1 / Th 2 cytokine profiles in the nasopharyngeal lymphoid tissues of children with recurrent otitis media -
G. Ciprandi, I. Cirillo, A. Vizzaccaro, M. Milanese, M. Tosca (2004)
Nasal Obstruction in Patients with Seasonal Allergic Rhinitis: Relationships between Allergic Inflammation and Nasal AirflowInternational Archives of Allergy and Immunology, 134
-
M. Ivarsson, C. Lundberg, M. Quiding-Järbrink (2004)
Antibody production directed against pneumococci by immunocytes in the adenoid surface secretion.International journal of pediatric otorhinolaryngology, 68 5
-
M. Avanzini, A. Ricci, C. Scaramuzza, L. Semino, F. Pagella, A. Castellazzi, M. Marconi, Catherine Klersy, Angela Pistorio, A. Boner, Gian Marseglia (2006)
Deficiency of INFγ Producing Cells in Adenoids of Children Exposed to Passive SmokeInternational Journal of Immunopathology and Pharmacology, 19
-
J Bernstein, H. Faden, D Dryja, Jean Wactawski-Wende (1993)
Micro-ecology of the nasopharyngeal bacterial flora in otitis-prone and non-otitis-prone children.Acta oto-laryngologica, 113 1
-
K. Schroder, P. Hertzog, T. Ravasi, D. Hume (2004)
Interferon‐γ: an overview of signals, mechanisms and functionsJournal of Leukocyte Biology, 75
-
J. Bernstein, S. Xiang, M. Ballow, K. O'Neil (1998)
Th1/Th2 Cytokine Profiles in the Nasopharyngeal Lymphoid Tissues of Children with Recurrent Otitis MediaAnnals of Otology, Rhinology & Laryngology, 107
-
A. Ebenfelt, M. Ivarsson (2001)
Neutrophil migration in tonsilsJournal of Anatomy, 198
-
(1998)
Th2 cytokine profiles in the nasopharyngeal lymphoid tissues of children with recurrent otitis media -
N. Surgery (2004)
Otitis media with effusion.Pediatrics, 113 5
-
B. Foster, C. Prussin, Fei Liu, J. Whitmire, J. Whitton (2002)
Detection of Intracellular Cytokines by Flow CytometryCurrent Protocols in Immunology, 78
-
K. Schroder, P. Hertzog, T. Ravasi, D. Hume (2004)
Interferon-gamma: an overview of signals, mechanisms and functions.Journal of leukocyte biology, 75 2
-
(1993)
Are thymus-derived cells (T cells) defective in the nasopharyngeal and palatine tonsils of children -
Dreborg (1989)
EAACI Subcommittee on skin tests. Skin tests used in type I allergy testing. Position paperAllergy, 44
-
P. Brandtzaeg, F. Jahnsen, I. Farstad, G. Haraldsen (1997)
Mucosal Immunology of the Upper Airways: An Overview aAnnals of the New York Academy of Sciences, 830
-
J. Bernstein, M. Ballow, G. Rich (2001)
Detection of Intracytoplasmic Cytokines by Flow Cytometry in Adenoids and Peripheral Blood Lymphocytes of ChildrenAnnals of Otology, Rhinology & Laryngology, 110
-
P. Auinger, B. Lanphear, H. Kalkwarf, Mona Mansour (2003)
Trends in otitis media among children in the United States.Pediatrics, 112 3 Pt 1
-
M. Suzuki, T. Watanabe, G. Mogi (1999)
Clinical, bacteriological, and histological study of adenoids in children.American journal of otolaryngology, 20 2
-
EAACI Subcommittee on skin tests . Skin tests used in type I -
T. Jung, U. Schauer, C. Heusser, C. Neumann, C. Rieger (1993)
Detection of intracellular cytokines by flow cytometry.Journal of immunological methods, 159 1-2
-
J. Bernstein, G. Rich, C. Odziemiec, M. Ballow (1993)
Are Thymus-Derived Lymphocytes (T Cells) Defective in the Nasopharyngeal and Palatine tonsils of Children?Otolaryngology–Head and Neck Surgery, 109
-
(1989)
EAACI Subcommittee on skin tests. Skin tests used in type I allergy testing -
(2004)
Subcommittee on Management of Acute Otitis Media -
J. Bernstein, M. Reddy, F. Scannapieco, H. Faden, M. Ballow (1997)
The Microbial Ecology and Immunology of the Adenoid: Implications for Otitis MediaAnnals of the New York Academy of Sciences, 830
-
Siti Ilmyasri (2019)
Diagnosis and Management of Acute Otitis MediaJurnal Penelitian Perawat Profesional
- Publisher
- Wiley
- Copyright
- © 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
- ISSN
- 0905-6157
- eISSN
- 1399-3038
- DOI
- 10.1111/j.1399-3038.2007.00682.x
- pmid
- 18266836
- Publisher site
- See Article on Publisher Site
Abstract
Infectious diseases are frequently observed in children and their recurrence represents a demanding challenge for the paediatrician. It has been hypothesized that a defective immune response may occur in these patients. The aim of the present study was to evaluate whether children presenting with recurrent otitis have a defective interferon (IFN)γ production by the lymphocytes of peripheral blood and of adenoid tissue, in comparison with children without recurrent otitis. Our study group was represented by 58 children undergoing adenoidectomy for adenoidal hypertrophy. They were subdivided into two groups according to the recurrence of otitis (≥3 per year) or not (<3 per year). Intracellular cytokine profile of lymphocyte subsets in adenoids and peripheral blood was evaluated by flow cytometry analysis. Children with recurrent otitis showed a significantly lower percentage of CD8+‐producing IFNγ cells in adenoids than children with <3 otitis per year (p = 0.003). The reduced capability of the adenoid cells to produce INF‐γ may induce a high susceptibility to the recurrence of otitis in children.
Journal
Pediatric Allergy and Immunology – Wiley
Published: Sep 1, 2008