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Chemically Modified Diatoms Biosilica for Bone Cell Growth with Combined Drug‐Delivery and Antioxidant Properties

Chemically Modified Diatoms Biosilica for Bone Cell Growth with Combined Drug‐Delivery and... Nanostructured biosilica produced by Thalassiosira weissflogii diatoms is covalently functionalized with the cyclic nitroxide 2,6,6‐tetramethylpiperidine‐N‐oxyl (TEMPO), an efficient scavenger of reactive oxygen species (ROS) in biological systems. Drug delivery properties of the TEMPO‐functionalized biosilica are studied for Ciprofloxacin, an antimicrobial thoroughly employed in orthopedic or dental implant related infections. The resulting TEMPO‐biosilica, combining Ciprofloxacin drug delivery with anti‐oxidant properties, is demonstrated to be a suitable material for fibroblasts and osteoblast‐like cells growth. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png ChemPlusChem Wiley

Chemically Modified Diatoms Biosilica for Bone Cell Growth with Combined Drug‐Delivery and Antioxidant Properties

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Publisher
Wiley
Copyright
Copyright © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
2192-6506
eISSN
2192-6506
DOI
10.1002/cplu.201402398
Publisher site
See Article on Publisher Site

Abstract

Nanostructured biosilica produced by Thalassiosira weissflogii diatoms is covalently functionalized with the cyclic nitroxide 2,6,6‐tetramethylpiperidine‐N‐oxyl (TEMPO), an efficient scavenger of reactive oxygen species (ROS) in biological systems. Drug delivery properties of the TEMPO‐functionalized biosilica are studied for Ciprofloxacin, an antimicrobial thoroughly employed in orthopedic or dental implant related infections. The resulting TEMPO‐biosilica, combining Ciprofloxacin drug delivery with anti‐oxidant properties, is demonstrated to be a suitable material for fibroblasts and osteoblast‐like cells growth.

Journal

ChemPlusChem – Wiley

Published: Jul 1, 2015

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