Access the full text.
Sign up today, get DeepDyve free for 14 days.
A. Filoteo, N. Elwess, Á. Enyedi, A. Caride, H. Aung, J. Penniston (1997)
Plasma Membrane Ca Pump in Rat Brain PATTERNS OF ALTERNATIVE SPLICES SEEN BY ISOFORM-SPECIFIC ANTIBODIES*
David Zacharias, Claudia Kappen (1999)
Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse.Biochimica et biophysica acta, 1428 2-3
P. Brandt, R. Neve (1992)
Expression of Plasma Membrane Calcium‐Pumping ATPase mRNAs in Developing Rat Brain and Adult Brain Subregions: Evidence for Stage‐Specific ExpressionJournal of Neurochemistry, 59
S. DeMarco, E. Strehler (2001)
Plasma Membrane Ca2+-ATPase Isoforms 2b and 4b Interact Promiscuously and Selectively with Members of the Membrane-associated Guanylate Kinase Family of PDZ (PSD95/Dlg/ZO-1) Domain-containing Proteins*The Journal of Biological Chemistry, 276
Katsumasa Takahashi, Ken Kitamura (1999)
A point mutation in a plasma membrane Ca(2+)-ATPase gene causes deafness in Wriggle Mouse Sagami.Biochemical and biophysical research communications, 261 3
B. Sabatini, M. Maravall, K. Svoboda (2001)
Ca2+ signaling in dendritic spinesCurrent Opinion in Neurobiology, 11
Thomas Jensen, L. Buckby, R. Empson (2004)
Expression of plasma membrane Ca2+ ATPase family members and associated synaptic proteins in acute and cultured organotypic hippocampal slices from rat.Brain research. Developmental brain research, 152 2
M. Berridge, M. Bootman, H. Roderick (2003)
Calcium: Calcium signalling: dynamics, homeostasis and remodellingNature Reviews Molecular Cell Biology, 4
R. Fitzsimonds, Hong-jun Song, M. Poo (1997)
Propagation of activity-dependent synaptic depression in simple neural networksNature, 388
T. Stauffer, D. Guerini, E. Carafoli (1995)
Tissue distribution of the four gene products of the plasma membrane Ca2+ pump. A study using specific antibodies.The Journal of biological chemistry, 270 20
D. Zacharias, N. Garamszegi, E. Strehler (1994)
Characterization of persistent artifacts resulting from RT-PCR of alternatively spliced mRNAs.BioTechniques, 17 4
Xiao-fang Li, J. Lytton (2002)
Differential Expression of Na/Ca Exchanger and Na/Ca + K Exchanger Transcripts in Rat BrainAnnals of the New York Academy of Sciences, 976
G. Augustine, F. Santamaría, Keiko Tanaka (2003)
Local Calcium Signaling in NeuronsNeuron, 40
A. Araque, V. Parpura, R. Sanzgiri, P. Haydon (1999)
Tripartite synapses: glia, the unacknowledged partnerTrends in Neurosciences, 22
Peter Kozel, R. Friedman, L. Erway, E. Yamoah, Lynne Liu, Tara Riddle, J. Duffy, T. Doetschman, Marian Miller, E. Cardell, G. Shull (1998)
Balance and Hearing Deficits in Mice with a Null Mutation in the Gene Encoding Plasma Membrane Ca2+-ATPase Isoform 2*The Journal of Biological Chemistry, 273
M. Blaustein, W. Lederer (1999)
Sodium/calcium exchange: its physiological implications.Physiological reviews, 79 3
E. Carafoli, L. Santella, D. Branca, M. Brini (2001)
Generation, Control, and Processing of Cellular Calcium SignalsCritical Reviews in Biochemistry and Molecular Biology, 36
Xinjiang Cai, J. Lytton (2004)
Molecular Cloning of a Sixth Member of the K+-dependent Na+/Ca2+ Exchanger Gene Family, NCKX6*Journal of Biological Chemistry, 279
A. Craig, C. Blackstone, R. Huganir, G. Banker (1993)
The distribution of glutamate receptors in cultured rat hippocampal neurons: Postsynaptic clustering of AMPA selective subunitsNeuron, 10
Targeted ablation of plasma membrane Ca 2+ -ATPase
V. Street, J. McKee-Johnson, Rosalia Fonseca, B. Tempel, K. Noben‐Trauth (1998)
Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler miceNature Genetics, 19
M. Mattson, S. Barger (1993)
Roles for calcium signaling in structural plasticity and pathology in the hippocampal systemHippocampus, 3
Kirk Ririe, R. Rasmussen, C. Wittwer (1997)
Product differentiation by analysis of DNA melting curves during the polymerase chain reaction.Analytical biochemistry, 245 2
D. Choi (1995)
Calcium: still center-stage in hypoxic-ischemic neuronal deathTrends in Neurosciences, 18
James Zheng (2000)
Turning of nerve growth cones induced by localized increases in intracellular calcium ionsNature, 403
H. Furuta, L. Luo, K. Hepler, A. Ryan (1998)
Evidence for differential regulation of calcium by outer versus inner hair cells: plasma membrane Ca-ATPase gene expressionHearing Research, 123
Michael Tsoi, Kyung-Hwa Rhee, D. Bungard, Xiao-fang Li, Shwu-Luan Lee, R. Auer, J. Lytton (1998)
Molecular Cloning of a Novel Potassium-dependent Sodium-Calcium Exchanger from Rat Brain*The Journal of Biological Chemistry, 273
G. Brewer (1995)
Serum‐free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrusJournal of Neuroscience Research, 42
O. Petersen, J. Cancela (2000)
Nerve guidance: Attraction or repulsion by local Ca2+ signalsCurrent Biology, 10
M. Cousin, P. Robinson (2000)
Ca2+ Influx Inhibits Dynamin and Arrests Synaptic Vesicle Endocytosis at the Active ZoneThe Journal of Neuroscience, 20
M. Evans, Melissa Collings, G. Brewer (1998)
Electrophysiology of embryonic, adult and aged rat hippocampal neurons in serum-free cultureJournal of Neuroscience Methods, 79
L. Fresu, Ahmed Dehpour, A. Genazzani, E. Carafoli, D. Guerini (1999)
Plasma membrane calcium ATPase isoforms in astrocytesGlia, 28
S. Lee, M. Sheng (2000)
Development of neuron–neuron synapsesCurrent Opinion in Neurobiology, 10
A. Rao, Eunjoon Kim, M. Sheng, A. Craig (1998)
Heterogeneity in the Molecular Composition of Excitatory Postsynaptic Sites during Development of Hippocampal Neurons in CultureThe Journal of Neuroscience, 18
C. Wang, N. Davis, R. Colvin (1997)
Genistein inhibits Na+/Ca2+ exchange activity in primary rat cortical neuron culture.Biochemical and biophysical research communications, 233 1
Rachel Dumont, U. Lins, A. Filoteo, J. Penniston, B. Kachar, P. Gillespie (2001)
Plasma Membrane Ca2+-ATPase Isoform 2a Is the PMCA of Hair BundlesThe Journal of Neuroscience, 21
(1998)
Current Protocols in Molecular Biology
Xiao-fang Li, A. Kraev, J. Lytton (2002)
Molecular Cloning of a Fourth Member of the Potassium-dependent Sodium-Calcium Exchanger Gene Family, NCKX4*The Journal of Biological Chemistry, 277
A. Caride, A. Filoteo, Á. Enyedi, A. Verma, J. Penniston (1996)
Detection of isoform 4 of the plasma membrane calcium pump in human tissues by using isoform-specific monoclonal antibodies.The Biochemical journal, 316 ( Pt 1)
S. DeMarco, E. Strehler (2001)
Plasma Membrane Ca-ATPase Isoforms 2b and 4b Interact Promiscuously and Selectively with Members of the Membrane-associated Guanylate Kinase Family of PDZ (PSD95/Dlg/ZO-1) Domain-containing Proteins*
R. Burgoyne, A. Morgan (1995)
Ca2+ and secretory-vesicle dynamicsTrends in Neurosciences, 18
S. Kip, E. Strehler (2003)
Characterization of PMCA isoforms and their contribution to transcellular Ca2+ flux in MDCK cells.American journal of physiology. Renal physiology, 284 1
Gbolahan Okunade, Marian Miller, G. Pyne, R. Sutliff, Kyle O'Connor, J. Neumann, A. Andringa, Daniel Miller, V. Prasad, T. Doetschman, R. Paul, G. Shull (2004)
Targeted Ablation of Plasma Membrane Ca2+-ATPase (PMCA) 1 and 4 Indicates a Major Housekeeping Function for PMCA1 and a Critical Role in Hyperactivated Sperm Motility and Male Fertility for PMCA4*Journal of Biological Chemistry, 279
L. Kiedrowski (2004)
High activity of K+-dependent plasmalemmal Na+/Ca2+ exchangers in hippocampal CA1 neuronsNeuroReport, 15
A. Filoteo, N. Elwess, Á. Enyedi, A. Caride, H. Aung, J. Penniston (1997)
Plasma Membrane Ca2+ Pump in Rat BrainThe Journal of Biological Chemistry, 272
D. Križaj, S. DeMarco, Juliette Johnson, E. Strehler, D. Copenhagen (2002)
Cell‐specific expression of plasma membrane calcium ATPase isoforms in retinal neuronsJournal of Comparative Neurology, 451
R. Zucker (1999)
Calcium- and activity-dependent synaptic plasticityCurrent Opinion in Neurobiology, 9
R. Sattler, M. Tymianski (2000)
Molecular mechanisms of calcium-dependent excitotoxicityJournal of Molecular Medicine, 78
M. Mattson, R. Rydel, I. Lieberburg, V. Smith-Swintosky (1993)
Altered Calcium Signaling and Neuronal Injury: Stroke and Alzheimer's Disease as Examples aAnnals of the New York Academy of Sciences, 679
Eunjoon Kim, S. DeMarco, S. Marfatia, A. Chishti, M. Sheng, E. Strehler (1998)
Plasma Membrane Ca2+ ATPase Isoform 4b Binds to Membrane-associated Guanylate Kinase (MAGUK) Proteins via Their PDZ (PSD-95/Dlg/ZO-1) Domains*The Journal of Biological Chemistry, 273
E. Strehler, D. Zacharias (2001)
Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.Physiological reviews, 81 1
Peter Kozel, Rickie Davis, E. Krieg, G. Shull, L. Erway (2002)
Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in miceHearing Research, 164
J. Lytton, Xiao-fang Li, Hui Dong, A. Kraev (2002)
K+‐Dependent Na+/Ca2+ Exchangers in the BrainAnnals of the New York Academy of Sciences, 976
William Stahl, T. Eakin, JAMES Owens, J. Breininger, P. Filuk, W. Anderson (1992)
Plasma membrane Ca(2+)-ATPase isoforms: distribution of mRNAs in rat brain by in situ hybridization.Brain research. Molecular brain research, 16 3-4
D. Zacharias, S. Dalrymple, E. Strehler (1995)
Transcript distribution of plasma membrane Ca2+ pump isoforms and splice variants in the human brain.Brain research. Molecular brain research, 28 2
M. Papa, Adriana Canitano, F. Boscia, P. Castaldo, S. Sellitti, H. Porzig, M. Taglialatela, L. Annunziato (2003)
Differential expression of the Na+‐Ca2+ exchanger transcripts and proteins in rat brain regionsJournal of Comparative Neurology, 461
A. Burette, J. Rockwood, E. Strehler, R. Weinberg (2003)
Isoform‐specific distribution of the plasma membrane Ca2+ ATPase in the rat brainJournal of Comparative Neurology, 467
P. Haydon (2001)
Glia: listening and talking to the synapseNature Reviews Neuroscience, 2
B. Quednau, D. Nicoll, K. Philipson (1997)
Tissue specificity and alternative splicing of the Na+/Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in rat.The American journal of physiology, 272 4 Pt 1
T. Green, K. Stauffer, S. Lummis (1995)
Expression of Recombinant Homo-oligomeric 5-Hydroxytryptamine Receptors Provides New Insights into Their Maturation and Structure (*)The Journal of Biological Chemistry, 270
A. Kraev, B. Quednau, S. Leach, Xiao-fang Li, Hui Dong, R. Winkfein, Marco Perizzolo, Xinjiang Cai, Ruomei Yang, K. Philipson, J. Lytton (2001)
Molecular Cloning of a Third Member of the Potassium-dependent Sodium-Calcium Exchanger Gene Family,NCKX3 *The Journal of Biological Chemistry, 276
Kyonsoo Hong, M. Nishiyama, J. Henley, M. Tessier-Lavigne, M. Poo (2000)
Calcium signalling in the guidance of nerve growth by netrin-1Nature, 403
H. Higuchi, S. Bronk, M. Taniai, A. Canbay, G. Gores (2002)
Cholestasis Increases Tumor Necrosis Factor-Related Apoptotis-Inducing Ligand (TRAIL)-R2/DR5 Expression and Sensitizes the Liver to TRAIL-Mediated CytotoxicityJournal of Pharmacology and Experimental Therapeutics, 303
T. Thurneysen, D. Nicoll, K. Philipson, H. Porzig (2002)
Sodium/calcium exchanger subtypes NCX1, NCX2 and NCX3 show cell-specific expression in rat hippocampus cultures.Brain research. Molecular brain research, 107 2
L. Yu, R. Colvin (1997)
Regional differences in expression of transcripts for Na+/Ca2+ exchanger isoforms in rat brain.Brain research. Molecular brain research, 50 1-2
C. Dotti, C. Sullivan, G. Banker (1988)
The establishment of polarity by hippocampal neurons in culture, 8
Berridge Berridge, Bootman Bootman, Roderick Roderick (2003)
Calcium signalling: dynamics, homeostasis and remodellingNat Rev Mol Cell Biol, 4
T. Stauffer, D. Guerini, M. Celio, E. Carafoli (1997)
Immunolocalization of the plasma membrane Ca2+ pump isoforms in the rat brainBrain Research, 748
(1991)
Rat hippocampal neurons in low density culture
Russell Higuchi, Carita Fockler, G. Dollinger, R. Watson (1993)
Kinetic PCR Analysis: Real-time Monitoring of DNA Amplification ReactionsBio/Technology, 11
P. Brandt, Rachael Neve, A. Kammesheidt, Robert Rhoads, T. Vanaman (1992)
Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels.The Journal of biological chemistry, 267 7
Spatial and temporal control of intracellular calcium signaling is essential for neuronal development and function. The termination of local Ca2+ signaling and the maintenance of basal Ca2+ levels require specific extrusion systems in the plasma membrane. In rat hippocampal neurons (HNs) developing in vitro, transcripts for all isoforms of the plasma membrane Ca2+ pump and the Na/Ca2+ exchanger, and the major nonphotoreceptor Na+/Ca2+,K+ exchangers (NCKX) were strongly upregulated during the second week in culture. Upregulation of plasma membrane calcium ATPases (PMCAs)1, 3, and 4 mRNA coincided with a splice shift from the ubiquitous b‐type to the neuron‐specific a‐type with altered calmodulin regulation. Expression of all PMCA isoforms increased over 5‐fold during the first 2 weeks. PMCA immunoreactivity was initially concentrated in the soma and growth cones of developing HNs. As the cells matured, PMCAs concentrated in the dendritic membrane and often colocalized with actin‐rich dendritic spines in mature neurons. In the developing rat hippocampal CA1 region, immunohistochemistry confirmed the upregulation of all PMCAs and showed that by the end of the second postnatal week, PMCAs1, 2, and 3 were concentrated in the neuropil, with less intense staining of cell bodies in the pyramidal layer. PMCA4 staining was restricted to a few cells showing intense labeling of the cell periphery and neurites. These results establish that all major Ca2+ extrusion systems are strongly upregulated in HNs during the first 2 weeks of postnatal development. The overall increase in Ca2+ extrusion systems is accompanied by changes in the expression and cellular localization of different isoforms of the Ca2+ pumps and exchangers. The accumulation of PMCAs in dendrites and dendritic spines coincides with the functional maturation in these neurons, suggesting the importance of the proper spatial organization of Ca2+ extrusion systems for synaptic function and development. © 2005 Wiley‐Liss, Inc.
Hippocampus – Wiley
Published: Jan 1, 2006
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.