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Cetirizine for seasonal allergic rhinitis in children aged 2‐6 years

Cetirizine for seasonal allergic rhinitis in children aged 2‐6 years A total of 107 children of both sexes between 2 and 6 years of age with pollen‐indueed seasonal allergic rhinitis (SAR) were entered in a multicentre study of double‐blind parallel group design in which the effects of 5 mg cetirizine, given as drops from a solution containing 10 mg/ml once daily each evening for two weeks, were compared with those of identical placebo. Sneezing, rhinorrhea, nasal obstruction and nasal and ocular pruritus were the symptoms evaluated by means of symptom scores by investigators and on daily record cards, by parents. Investigators also made a global evaluation at the end of treatment. Cetirizine was more active than placebo for eaeh symptom evaluated both by parents and investigators. There were significant by more (p = 0.002) days during which symptoms were absent or mild, in the cetirizine than in the placebo group. When the maximum symptom scores rated by investigators at each visit were compared, the difference in favour of cetirizine at the end of treatment was statistically signifieant (p = 0.04). Global evaluation by investigators of changes in symptoms at the end of the study showed an improvement in both groups which was significantly greater with cetirizine. providing excellent or good improvement in 34/54 patients compared with 25/53 patients on placebo (p = 0.039). Toleranee was good. Three patients on cetirizine and none on placebo experienced mild somnolence. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Cetirizine for seasonal allergic rhinitis in children aged 2‐6 years

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References (5)

Publisher
Wiley
Copyright
Copyright © 1993 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.1993.tb00085.x
Publisher site
See Article on Publisher Site

Abstract

A total of 107 children of both sexes between 2 and 6 years of age with pollen‐indueed seasonal allergic rhinitis (SAR) were entered in a multicentre study of double‐blind parallel group design in which the effects of 5 mg cetirizine, given as drops from a solution containing 10 mg/ml once daily each evening for two weeks, were compared with those of identical placebo. Sneezing, rhinorrhea, nasal obstruction and nasal and ocular pruritus were the symptoms evaluated by means of symptom scores by investigators and on daily record cards, by parents. Investigators also made a global evaluation at the end of treatment. Cetirizine was more active than placebo for eaeh symptom evaluated both by parents and investigators. There were significant by more (p = 0.002) days during which symptoms were absent or mild, in the cetirizine than in the placebo group. When the maximum symptom scores rated by investigators at each visit were compared, the difference in favour of cetirizine at the end of treatment was statistically signifieant (p = 0.04). Global evaluation by investigators of changes in symptoms at the end of the study showed an improvement in both groups which was significantly greater with cetirizine. providing excellent or good improvement in 34/54 patients compared with 25/53 patients on placebo (p = 0.039). Toleranee was good. Three patients on cetirizine and none on placebo experienced mild somnolence.

Journal

Pediatric Allergy and Immunology – Wiley

Published: Aug 1, 1993

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