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J. Edwards (1972)
A marker algebraClinical Genetics, 3
J. Loutit (1967)
Cardiac PathologyBritish Medical Journal, 3
M. Mikkelsen (1970)
A DANISH SURVEY OF PATIENTS WITH DOWN'S SYNDROME BORN TO YOUNG MOTHERSAnnals of the New York Academy of Sciences, 171
M. Sasaki, Yukiko Hara, I. Uchida (1973)
PATERNAL ORIGIN OF THE EXTRA CHROMOSOME IN DOWN'S SYNDROMEThe Lancet, 302
(1971)
The interpretation of genetic markers in mongolism
Stanley Wright, Stanley Wright, Robert Day, Robert Day, Helga Muller, Helga Muller, Roger Weinhouse, Roger Weinhouse (1967)
The frequency of trisomy and translocation in Down's syndrome.The Journal of pediatrics, 70 3
BY G. B. C8TB* AND J. H. EDWARDS The Infant Development Unit, Birmingham Maternity Hospital, Queen Elizabeth Medical Centre, Birmingham B15 BTG, England Trisomies provide an additional way of observing the segregation of chromosomes and of the loci they carry. Apart from causing a specific syndrome, the extra chromosome should predictably affect the segregation pattern of the phenotypes defined a t the loci it carries. Analysis of its effects and the detection of linkage depend on a n understanding of the cytological mechanisms involved. In the model presented below, asynapsis, the non-pairing of two homologous chromosomes a t meiosis, is implied, and considered together with cases of non-disjunction at the first meiotic division. Let us consider two homologous chromosomes associated in a tetrad of four chromatids at the diplotene stage of meiosis (Fig. 1). If a cross-over occurs between a locus and its centromere, two of the four chromatids are recombinants, and two are non-recombinants (Fig. 2). Providing the chromatids are involved a t random, the average result will be the same for any number of cross-overs and there will be an equal number of apparent recombinant and non-recombinant chromatids (Fig. 3). We will use the word âchromatidâ
Annals of Human Genetics – Wiley
Published: Jul 1, 1975
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