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Catheter‐directed thrombolysis for prevention of postthrombotic syndrome

Catheter‐directed thrombolysis for prevention of postthrombotic syndrome NNT color recommendationYellow (unclear if benefits)Abstract headingMay reduce postthrombotic syndrome in patients with deep vein thrombosisBenefits in NNT1 in 10 were helped (postthrombotic syndrome prevented in the overall study population)Benefits in percentages (absolute risk reduction)9.9% lower risk of postthrombotic syndromeHarms in NNT (NNH)No one was harmedHarms in percentagesNo one was harmedEfficacy endpointsPostthrombotic syndrome, patent iliofemoral veins, future venous thromboembolismHarm endpointsBleeding, all‐cause mortalityWho was in the studies4 trials of 1005 patients with deep vein thrombosisNARRATIVEClot formation in deep veins (deep vein thrombosis [DVT]), such as large veins in the lower extremities and pelvis, is common with an annual incidence approximating 900,000 in the United States.1,2 Some patients with DVT (20%–50%) develop long‐term complications such as postthrombotic syndrome (PTS).1‐3 PTS is manifested by signs and symptoms including swelling of the affected limb, pain, cramps, burning or prickling sensations (paresthesias), itching, redness, skin color change, and varicose vein formation.4 The severe form of PTS can cause skin ulcers from venous stasis.4 These chronic symptoms can reduce patient mobility, affect quality of life, and increase health care costs, particularly with moderate and severe disease. The severity of PTS is determined by grading systems such as the Villalta score.1‐3,5 This scoring system is composed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Academic Emergency Medicine Wiley

Catheter‐directed thrombolysis for prevention of postthrombotic syndrome

Long, Brit; Gottlieb, Michael
Academic Emergency Medicine , Volume 29 (4) – Apr 1, 2022
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References (18)

Publisher
Wiley
Copyright
Copyright © 2022 Society for Academic Emergency Medicine
ISSN
1069-6563
eISSN
1553-2712
DOI
10.1111/acem.14397
Publisher site
See Article on Publisher Site

Abstract

NNT color recommendationYellow (unclear if benefits)Abstract headingMay reduce postthrombotic syndrome in patients with deep vein thrombosisBenefits in NNT1 in 10 were helped (postthrombotic syndrome prevented in the overall study population)Benefits in percentages (absolute risk reduction)9.9% lower risk of postthrombotic syndromeHarms in NNT (NNH)No one was harmedHarms in percentagesNo one was harmedEfficacy endpointsPostthrombotic syndrome, patent iliofemoral veins, future venous thromboembolismHarm endpointsBleeding, all‐cause mortalityWho was in the studies4 trials of 1005 patients with deep vein thrombosisNARRATIVEClot formation in deep veins (deep vein thrombosis [DVT]), such as large veins in the lower extremities and pelvis, is common with an annual incidence approximating 900,000 in the United States.1,2 Some patients with DVT (20%–50%) develop long‐term complications such as postthrombotic syndrome (PTS).1‐3 PTS is manifested by signs and symptoms including swelling of the affected limb, pain, cramps, burning or prickling sensations (paresthesias), itching, redness, skin color change, and varicose vein formation.4 The severe form of PTS can cause skin ulcers from venous stasis.4 These chronic symptoms can reduce patient mobility, affect quality of life, and increase health care costs, particularly with moderate and severe disease. The severity of PTS is determined by grading systems such as the Villalta score.1‐3,5 This scoring system is composed

Journal

Academic Emergency Medicine – Wiley

Published: Apr 1, 2022

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