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Cancer genes – Management of carriers of breast cancer genes who have already developed cancer: the Carrier Clinic Model

Cancer genes – Management of carriers of breast cancer genes who have already developed cancer:... People who carry mutations in breast cancer susceptibility genes, and have already developed cancer, are managed by various different centres according to their needs. This issue of FACET highlights some of the concerns and difficulties for both the health professionals and the carriers themselves, and we suggest the need for all gene carriers to be followed up within a specialist group of health professionals trained both in oncology and genetics. The identification of breast cancer genes There are several rare inherited genetic disorders that are associated with early onset breast cancer. However, for the purpose of this article, the focus is on the BRCA 1 and BRCA 2 genes. Although not discussed in this section, there are other very rare highly penetrant genes. If mutated, they confer a very high risk of developing breast cancer and other cancers at very young ages. The chance of being a germline BRCA carrier in the general UK population is between 1 in 500 and 1 in 2500 (Ford et al. 1995). A person who is a carrier of a germline mutation in the BRCA 1 or BRCA 2 gene has the potential to pass the mutation on to his/her offspring. For http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Cancer Care Wiley

Cancer genes – Management of carriers of breast cancer genes who have already developed cancer: the Carrier Clinic Model

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Publisher
Wiley
Copyright
Copyright © 2002 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0961-5423
eISSN
1365-2354
DOI
10.1111/j.1365-2354.2002.00306.x
Publisher site
See Article on Publisher Site

Abstract

People who carry mutations in breast cancer susceptibility genes, and have already developed cancer, are managed by various different centres according to their needs. This issue of FACET highlights some of the concerns and difficulties for both the health professionals and the carriers themselves, and we suggest the need for all gene carriers to be followed up within a specialist group of health professionals trained both in oncology and genetics. The identification of breast cancer genes There are several rare inherited genetic disorders that are associated with early onset breast cancer. However, for the purpose of this article, the focus is on the BRCA 1 and BRCA 2 genes. Although not discussed in this section, there are other very rare highly penetrant genes. If mutated, they confer a very high risk of developing breast cancer and other cancers at very young ages. The chance of being a germline BRCA carrier in the general UK population is between 1 in 500 and 1 in 2500 (Ford et al. 1995). A person who is a carrier of a germline mutation in the BRCA 1 or BRCA 2 gene has the potential to pass the mutation on to his/her offspring. For

Journal

European Journal of Cancer Care – Wiley

Published: Mar 1, 2002

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