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References (24)
-
M. Loss, B. Vangerow, J. Schmidtko, R. Kunz, A. Jalali, H. Arends, M. Przemeck, H. Rückholt, M. Leuwer, F. Kaup, S. Rensing, E. Cozzi, D. White, J. Klempnauer, M. Winkler (2000)
Acute vascular rejection is associated with systemic complement activation ina pig‐to‐primate kidney xenograft modelXenotransplantation, 7
-
Jeffrey Platt, Richard Fischel, A. Matas, Sally Reif, R. Bolman, Fritz Bach (1991)
Immunopathology of hyperacute xenograft rejection in a swine-to-primate model.Transplantation, 52 2
-
J. Leventhal (1997)
Removal of Natural Antibodies by Immunoadsorption: Results of Experimental Studies -
A. Zaidi, M. Schmoeckel, F. Bhatti, P. Waterworth, M. Tolan, E. Cozzi, G. Chavez, G. Langford, S. Thiru, J. Wallwork, D. White, P. Friend (1998)
Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors.Transplantation, 65 12
-
M. Loss, J. Schmidtko, M. Przemeck, R. Kunz, H. Arends, A. Jalali, R. Lorenz, S. Piepenbrock, J. Klempnauer, M. Winkler (2001)
A primate model for discordant pig to primate kidney xenotransplantation without hyperacute graft rejection.Journal of investigative surgery : the official journal of the Academy of Surgical Research, 14 1
-
E. Cozzi, S. Masroor, B. Soin, C. Vial, David White (2000)
Progress in xenotransplantation.Clinical nephrology, 53 4
-
D. White, T. Oglesby, M. Liszewski, I. Tedja, D. Hourcade, M.-W. Wang, L. Wright, J. Wallwork, J. Atkinson (1992)
Expression of human decay accelerating factor or membrane cofactor protein genes on mouse cells inhibits lysis by human complementTransplant International, 5
-
E. Cozzi, D. White (1995)
The generation of transgenic pigs as potential organ donors for humansNature Medicine, 1
-
K. Sato, K. Takigami, T. Miyatake, E. Czismadia, D. Latinne, H. Bazin, F. Bach, M. Soares (1999)
Suppression of delayed xenograft rejection by specific depletion of elicited antibodies of the IgM isotype.Transplantation, 68 6
-
Tsukasa Miyatake, Koichiro Sato, K. Takigami, N. Koyamada, W. Hancock, H. Bazin, D. Latinne, F. Bach, M. Soares (1998)
Complement-fixing elicited antibodies are a major component in the pathogenesis of xenograft rejection.Journal of immunology, 160 8
-
T. Sablinski, P. Gianello, M. Bailin, K. Bergen, D. Emery, J. Fishman, A. Foley, T. Hatch, R. Hawley, T. Kozłowski, T. Lorf, S. Meehan, R. Monroy, J. Powelson, R. Colvin, A. Cosimi, D. Sachs (1997)
Pig to monkey bone marrow and kidney xenotransplantation.Surgery, 121 4
-
A. Dalmasso, J. Platt (1993)
Prevention of complement-mediated activation of xenogeneic endothelial cells in an in vitro model of xenograft hyperacute rejection by C1 inhibitor.Transplantation, 56 5
-
M. Kirschfink, W. Nürnberger (1999)
C1 inhibitor in anti-inflammatory therapy: from animal experiment to clinical application.Molecular immunology, 36 4-5
-
R. Calne (1970)
Organ transplantation between widely disparate species.Transplantation proceedings, 2 4
-
J. Platt, S. Lin, C. McGregor (2000)
Acute vascular rejection.Xenotransplantation, 5 3
-
P. Waterworth, E. Cozzi, M. Tolan, G. Langford, P. Braidley, G. Chavez, J. Dunning, J. Wallwork, D. White (1997)
Pig-to-primate cardiac xenotransplantation and cyclophosphamide therapy.Transplantation proceedings, 29 1-2
-
H. Auchincloss, J. Allan, A. Benedi, John Coffin, F. Hollinger, R. Kagan, Richard Kaslow, K. Knowles, W. Lawrence, N. Lerche, J. Linden, R. McCauley, C. Mickelson, K. Nelson, David Onions, P. Paul, Daniel Salomon, H. Vanderpool, Jay Siegel, Philip Noguchi, Eda Bloom, Carolyn Wilson, Jay Epstein, A. Dayton, R. Solomon, C. Silverman, P. Hudson, Louisa Chapman, S. Rose, G. Dapolito (1999)
Report of the Food and Drug Administration Subcommittee on Xenotransplantation: meeting of 13 January 2000, Center for Biologics Evaluation and ResearchXenotransplantation, 7
-
R. Chen, A. Kadner, R. Mitchell, D. Adams (2000)
Mechanism of delayed rejection in transgenic pig-to-primate cardiac xenotransplantation.The Journal of surgical research, 90 2
-
H. Auchincloss, J. Allan, M. Hirsch, R. Kaslow, A. Meyers, C. Mickelson, D. Onions, D. Ph, D. Sachs, D. Salomon, H. Vanderpool, LeRoy Walters, D. Cooper, E. Bloom, L. Marzella, P. Noguchi, D. M., J. Siegel, K. Weiss, Carolyn Wilson (1999)
Report of the Food and Drug Administration Subcommittee on Xenotransplantation: meeting of 3 and 4 June, 1999, Center for Biologics Evaluation and ResearchXenotransplantation, 6
-
C. Caliezi, W. Wuillemin, S. Zeerleder, M. Redondo, B. Eisele, C. Hack (2000)
C1-Esterase inhibitor: an anti-inflammatory agent and its potential use in the treatment of diseases other than hereditary angioedema.Pharmacological reviews, 52 1
-
M. Loss, R. Kunz, M. Przemeck, J. Schmidtko, H. Arends, A. Jalali, R. Lorenz, S. Piepenbrock, J. Klempnauer, M. Winkler (2000)
Influence of cold ischemia time, pretransplant anti-porcine antibodies, and donor/recipient size matching on hyperacute graft rejection after discordant porcine to cynomolgus kidney transplantation.Transplantation, 69 6
-
B. Heckl-Ostreicher, A. Wosnik, M. Kirschfink (1996)
Protection of porcine endothelial cells from complement-mediated cytotoxicity by the human complement regulators CD59, C1 inhibitor, and soluble complement receptor type 1. Analysis in a pig-to-human in vitro model relevant to hyperacute xenograft rejection.Transplantation, 62 11
-
T. Besse, L. Duck, D. Latinne, P. Gianello, J. Squifflet, M. Lievens, J. Tomasi, E. Lavenne-Pardonge, L. Lambotte, G. Alexandre (1994)
Effect of plasmapheresis and splenectomy on parameters involved in vascular rejection of discordant xenografts in the swine to baboon model.Transplantation proceedings, 26 2
-
K. McCurry, W. Parker, A. Cotterell, B. Weidner, Shu-sen Lin, L. Daniels, Z. Holzknecht, G. Byrne, L. Diamond, J. Logan, J. Platt (1997)
Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation.Human immunology, 58 2
- Publisher
- Wiley
- Copyright
- Copyright © 2001 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0908-665X
- eISSN
- 1399-3089
- DOI
- 10.1034/j.1399-3089.2001.00130.x
- Publisher site
- See Article on Publisher Site
Abstract
Abstract: At present, the major barrier to successful discordant xenotransplantation of unmodified or complement regulator transgenic porcine xenografts is acute vascular xenograft rejection (AVR). AVR is associated with the intragraft deposition of induced recipient xenoreactive antibodies and subsequent complement activation. In a life‐supporting pig to primate kidney xenotransplantation setting using h‐DAF transgenic donor organs and postoperative immunosuppression, episodes of AVR were either treated with boluses of cyclophosphamide and steroids or with the same regimen supplemented by a three‐day course of C1‐Inhibitor, a multifunctional complement regulator. In 8 out of 10 animals stable initial graft function was achieved; in all animals one or more episodes of AVR were observed. When, in 4 animals, C1‐Inhibitor was added to the standard anti‐rejection treatment regimen, AVR was successfully reversed in 6 out of 7 episodes, while in another group of 4 animals receiving the standard anti‐rejection treatment 0 out of 4 episodes of AVR responded to treatment. Response to anti‐rejection treatment was associated with a significant increase in recipient survival time. We conclude that AVR of h‐DAF transgenic porcine kidneys can be successfully treated by additional short‐term fluid phase complement inhibition.
Journal
Xenotransplantation – Wiley
Published: Nov 1, 2001