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- Publisher
- Wiley
- Copyright
- © 2021 Wiley‐VCH GmbH
- ISSN
- 2193-5807
- eISSN
- 2193-5815
- DOI
- 10.1002/ajoc.202100407
- Publisher site
- See Article on Publisher Site
Abstract
1,2,3,4‐tetrahydroisoquinoline (THIQ) and its derivatives possess a widespread biochemical, pharmaceutical and biological properties and they are the key building blocks in the structure of drugs and natural alkaloids. Accordingly, construction of multi‐substituted and polycyclic THIQs through functionalization of THIQs at different positions especially at C1‐position have come to the center of attraction in recent studies. In this review, we've focused on the classification of C1‐functionalization of THIQs in the research articles from 2013 on, including a brief description of the reaction mechanisms for the synthesis of multi‐substituted and polycyclic THIQs based on the type of substituents at the 1‐position of the THIQ moiety. From this point of view, the main categories are C1‐Functionalization and C1‐Functionalization with annulation.
Journal
Asian Journal of Organic Chemistry – Wiley
Published: Oct 1, 2021
Keywords: C1-functionalization; THIQs; Azomethine ylides; Tetrahydroisoquinolines; Iminium intermediates