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breastfeeding; Rint; FeNO; wheezing; Background: Breastfeeding is associated with a lower risk of asthma symptoms in early asthma childhood, but its effect at older ages remains unclear. We examined the associations of duration and exclusiveness of breastfeeding with asthma outcomes in children aged Correspondence 6 years, and whether these associations were explained by atopic or infectious Liesbeth Duijts, Erasmus MC, University mechanisms. Medical Center, Sp-3435, PO Box 2060, Methods: We performed a population-based prospective cohort study among 5675 3000 CB Rotterdam, The Netherlands. children. Information about breastfeeding was collected by questionnaires. At age Tel.: +031 107036263 Fax: +031 10 7036811 6 years, we measured interrupter resistance (Rint) and fractional exhaled nitric oxide E-mail: l.duijts@erasmusmc.nl (FeNO). Information about wheezing patterns (early (≤3 years only), late (>3 years only), persistent (≤3 and >3 years)), and current asthma at 6 years was derived from Accepted for publication 5 April 2016 repeated questionnaires. Results: Compared to children who were ever breastfed, those who were never DOI:10.1111/pai.12576 breastfed had lower FeNO levels (sympercent (95% CI): -16.0 (-24.5, -7.5)) and increased risks of late and persistent wheezing (OR(95% CI): 1.69 (1.06, 2.69) and 1.44 (1.00, 2.07), respectively). Shorter duration of breastfeeding was associated with early
Pediatric Allergy and Immunology – Wiley
Published: Aug 1, 2016
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