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Blood‐group gene localization through a study of mongolism

Blood‐group gene localization through a study of mongolism Summary Eighty‐two mongol‐sib pairs and their parents at Liverpool and eighty‐two mongol‐sib pairs at Buffalo, New York, have been investigated. Their blood was examined for A, A, BO, Lewis, MNSs, Rh, P., Duffy and Kell groups in all, and for Lutheran, Kidd, Vw, Mia and DP in addition in the Buffalo series. Their salivas were tested for ABH secretor status. Results have been added to the previous data of Lang‐Brown et al. (1952/63) and show no significant association between blood‐group phenotype and mongolism, except in the cme of Kell, where a significant excess of Kell‐positive mongols is found. The possibility that the Kell locus may therefore be on chromosome 21 is discussed. No significant difference between mongols and their normal sibs is found in urinary fucose excretion. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Blood‐group gene localization through a study of mongolism

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References (13)

Publisher
Wiley
Copyright
Copyright © 1966 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1966.tb00006.x
Publisher site
See Article on Publisher Site

Abstract

Summary Eighty‐two mongol‐sib pairs and their parents at Liverpool and eighty‐two mongol‐sib pairs at Buffalo, New York, have been investigated. Their blood was examined for A, A, BO, Lewis, MNSs, Rh, P., Duffy and Kell groups in all, and for Lutheran, Kidd, Vw, Mia and DP in addition in the Buffalo series. Their salivas were tested for ABH secretor status. Results have been added to the previous data of Lang‐Brown et al. (1952/63) and show no significant association between blood‐group phenotype and mongolism, except in the cme of Kell, where a significant excess of Kell‐positive mongols is found. The possibility that the Kell locus may therefore be on chromosome 21 is discussed. No significant difference between mongols and their normal sibs is found in urinary fucose excretion.

Journal

Annals of Human GeneticsWiley

Published: Jul 1, 1966

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