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BDNF is required for the induction of a presynaptic component of the functional conversion of silent synapses

BDNF is required for the induction of a presynaptic component of the functional conversion of... Long‐term potentiation (LTP) has received attention because of its proposed role in learning and memory. Despite substantial effort the pre‐ or postsynaptic expression site of LTP remains unsettled. It has been proposed that LTP is expressed postsynaptically through the functional conversion of “silent synapses.” We had shown that Schaffer collateral (SC) silent and “functional synapses,” which lack and express AMPA receptors, respectively exhibit distinct transmitter release properties. Therefore the functional conversion of silent synapses with LTP should be associated with presynaptic modifications. We now show that the pairing‐induced LTP at SC synapses is mediated by combined pre‐ and postsynaptic modifications involving the postsynaptic emergence of an AMPA response coupled with an enhanced glutamate release. BDNF replicates the changes associated with this LTP by activating TrkBRs, suggesting that the neurotrophin is required for the coordinated changes on both sides of the synaptic cleft. © 2010 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hippocampus Wiley

BDNF is required for the induction of a presynaptic component of the functional conversion of silent synapses

Cabezas, Carolina; Buño, Washington
Hippocampus , Volume 21 (4) – Apr 1, 2011
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References (90)

Publisher
Wiley
Copyright
Copyright © 2009 Wiley‐Liss, Inc.
ISSN
1050-9631
eISSN
1098-1063
DOI
10.1002/hipo.20754
pmid
20082298
Publisher site
See Article on Publisher Site

Abstract

Long‐term potentiation (LTP) has received attention because of its proposed role in learning and memory. Despite substantial effort the pre‐ or postsynaptic expression site of LTP remains unsettled. It has been proposed that LTP is expressed postsynaptically through the functional conversion of “silent synapses.” We had shown that Schaffer collateral (SC) silent and “functional synapses,” which lack and express AMPA receptors, respectively exhibit distinct transmitter release properties. Therefore the functional conversion of silent synapses with LTP should be associated with presynaptic modifications. We now show that the pairing‐induced LTP at SC synapses is mediated by combined pre‐ and postsynaptic modifications involving the postsynaptic emergence of an AMPA response coupled with an enhanced glutamate release. BDNF replicates the changes associated with this LTP by activating TrkBRs, suggesting that the neurotrophin is required for the coordinated changes on both sides of the synaptic cleft. © 2010 Wiley‐Liss, Inc.

Journal

Hippocampus – Wiley

Published: Apr 1, 2011

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