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Bayesian algorithms for recovering structure from single‐particle diffraction snapshots of unknown orientation: a comparison

Bayesian algorithms for recovering structure from single‐particle diffraction snapshots of... The advent of X‐ray free‐electron lasers promises the possibility to determine the structure of individual particles such as microcrystallites, viruses and biomolecules from single‐shot diffraction snapshots obtained before the particle is destroyed by the intense femtosecond pulse. This program requires the ability to determine the orientation of the particle giving rise to each snapshot at signal levels as low as ~10−2 photons per pixel. Two apparently different approaches have recently demonstrated this capability. Here we show they represent different implementations of the same fundamental approach, and identify the primary factors limiting their performance. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Crystallographica Section A: Foundations and Advances Wiley

Bayesian algorithms for recovering structure from single‐particle diffraction snapshots of unknown orientation: a comparison

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References (14)

Publisher
Wiley
Copyright
Copyright © 2011 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0108-7673
eISSN
1600-5724
DOI
10.1107/S0108767311019611
pmid
21844653
Publisher site
See Article on Publisher Site

Abstract

The advent of X‐ray free‐electron lasers promises the possibility to determine the structure of individual particles such as microcrystallites, viruses and biomolecules from single‐shot diffraction snapshots obtained before the particle is destroyed by the intense femtosecond pulse. This program requires the ability to determine the orientation of the particle giving rise to each snapshot at signal levels as low as ~10−2 photons per pixel. Two apparently different approaches have recently demonstrated this capability. Here we show they represent different implementations of the same fundamental approach, and identify the primary factors limiting their performance.

Journal

Acta Crystallographica Section A: Foundations and AdvancesWiley

Published: Jan 1, 2011

Keywords: ;

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