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Base‐promoted Synthesis of Trifluoromethylated (1,3‐dioxolan‐4‐ylidene)methylphosphonates from Trifluoromethylketones and Ethynylphosphonates

Base‐promoted Synthesis of Trifluoromethylated (1,3‐dioxolan‐4‐ylidene)methylphosphonates from... Efficient synthesis of CF3‐functionalized 1,3‐dioxolane phosphonates via base‐catalyzed nucleophilic addition/cyclization of diethyl ethynylphosphonate or diethyl 3‐hydroxyprop‐1‐yn‐1‐ylphosphonates with trifluoromethylketones is described. Synthesis of various CF3‐substituted 1,3‐dioxolane derivatives in good to excellent yields with a broad range of substrates is described. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

Base‐promoted Synthesis of Trifluoromethylated (1,3‐dioxolan‐4‐ylidene)methylphosphonates from Trifluoromethylketones and Ethynylphosphonates

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Publisher
Wiley
Copyright
© 2021 Wiley‐VCH GmbH
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.202100428
Publisher site
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Abstract

Efficient synthesis of CF3‐functionalized 1,3‐dioxolane phosphonates via base‐catalyzed nucleophilic addition/cyclization of diethyl ethynylphosphonate or diethyl 3‐hydroxyprop‐1‐yn‐1‐ylphosphonates with trifluoromethylketones is described. Synthesis of various CF3‐substituted 1,3‐dioxolane derivatives in good to excellent yields with a broad range of substrates is described.

Journal

Asian Journal of Organic Chemistry – Wiley

Published: Oct 1, 2021

Keywords: 1,3-dioxolanes; phosphonates; organofluorine compounds; cyclization; alkynes

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