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(1962)
Chromosome aberrations induced by ionising radiations
(1964)
Cytogenetic studies in leukocytes on the general population
(1969)
Some algorithms for chromosome recognition
P. Moorhead, P. Nowell, W. Mellman, D. Battips, D. Hungerford (1960)
Chromosome preparations of leukocytes cultured from human peripheral blood.Experimental cell research, 20
J. Hamerton, H. Klinger, D. Mutton, E. Lang (1963)
THE LONDON CONFERENCE ON THE NORMAL HUMAN KARYOTYPE, 28TH-30TH AUGUST, 1963.Cytogenetics, 2
H. Evans (1962)
Chromosome Aberrations Induced by Ionizing RadiationsInternational Review of Cytology-a Survey of Cell Biology, 13
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Chromosome aberrations and exposure to ambient benzene . i , i f REFERENCES Sci . 157 , 1 , 339 . years and more
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CHROMOSOME ABERRATIONS AND EXPOSURE TO AMBIENT BENZENE.Lancet, 1 7387
P. Jacobs, M. Brunton, W. Brown (1963)
Cytogenetic studies in leucocytes on the general population: subjects of ages 65 years and moreAnnals of Human Genetics, 27
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Chromosome preparations of leukocytes cultured from human peripheral PATAU, K
A. Chaudhuri, K. Chaudhuri (1963)
The chromosome number in manThe Indian Journal of Pediatrics, 30
Here A is defined to make I;ZCK(s, t ) = 1, the sum being taken over integers only. Instead of adding unity to v(i,j) we add K(s, t ) to v(i + s , j + t ) for all relevant s
L. Nijenhius (1963)
The London Conference on ‘ The Normal Human Karyotype’ *Annals of Human Genetics, 27
K. Patau (1965)
Identification of Chromosomes
(1968)
Data structures for operations on digital images
M. Mendelsohn, T. Conway, D. Hungerford, W. Kolman, B. Perry, J. Prewitt (1966)
Computer-oriented analysis of human chromosomes. I. Photometric estimation of DNA content.Cytogenetics, 5 3
BY KEITH PATON MRC Computer Unit (London),242 Pentonville Road,London I. 1 ? INTRODUCTION The nucleus of a normal human cell is now known to contain forty-six chromosomes but this was not established until Tjio & Levan (1956) introduced a method which allowed the microscopic examination of individual chromosomes. This technique enables the cytologist to examine human cells in a form where the individual chromosomes are condensed to a few microns long and, in general, occupy distinct regions of the slide. Much interest has been shown in the question of dividing the forty-six chromosomes of the normal cell into recognizably distinct groups and the London report (1963) suggests that human beings can reliably distinguish ten such groups of chromosomes. I n this paper we consider the task of making these distinctions with a suitably programmed computer. To classify a chromosome is to assign it to one of the ten groups or to an eleventh group, that of abnormal chromosomes. The chromosomes are classified independently of one another using the maximum-likelihood method with two variables, relative size and centromeric index. I n principle, the success of this method depends on the extent of the overlap of the distributions corresponding to
Annals of Human Genetics – Wiley
Published: Oct 1, 1969
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