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Automatic chromosome identification by the maximum‐likelihood method

Automatic chromosome identification by the maximum‐likelihood method BY KEITH PATON MRC Computer Unit (London),242 Pentonville Road,London I. 1 ? INTRODUCTION The nucleus of a normal human cell is now known to contain forty-six chromosomes but this was not established until Tjio & Levan (1956) introduced a method which allowed the microscopic examination of individual chromosomes. This technique enables the cytologist to examine human cells in a form where the individual chromosomes are condensed to a few microns long and, in general, occupy distinct regions of the slide. Much interest has been shown in the question of dividing the forty-six chromosomes of the normal cell into recognizably distinct groups and the London report (1963) suggests that human beings can reliably distinguish ten such groups of chromosomes. I n this paper we consider the task of making these distinctions with a suitably programmed computer. To classify a chromosome is to assign it to one of the ten groups or to an eleventh group, that of abnormal chromosomes. The chromosomes are classified independently of one another using the maximum-likelihood method with two variables, relative size and centromeric index. I n principle, the success of this method depends on the extent of the overlap of the distributions corresponding to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Automatic chromosome identification by the maximum‐likelihood method

Annals of Human Genetics , Volume 33 (2) – Oct 1, 1969

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References (17)

Publisher
Wiley
Copyright
Copyright © 1969 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1969.tb01643.x
Publisher site
See Article on Publisher Site

Abstract

BY KEITH PATON MRC Computer Unit (London),242 Pentonville Road,London I. 1 ? INTRODUCTION The nucleus of a normal human cell is now known to contain forty-six chromosomes but this was not established until Tjio & Levan (1956) introduced a method which allowed the microscopic examination of individual chromosomes. This technique enables the cytologist to examine human cells in a form where the individual chromosomes are condensed to a few microns long and, in general, occupy distinct regions of the slide. Much interest has been shown in the question of dividing the forty-six chromosomes of the normal cell into recognizably distinct groups and the London report (1963) suggests that human beings can reliably distinguish ten such groups of chromosomes. I n this paper we consider the task of making these distinctions with a suitably programmed computer. To classify a chromosome is to assign it to one of the ten groups or to an eleventh group, that of abnormal chromosomes. The chromosomes are classified independently of one another using the maximum-likelihood method with two variables, relative size and centromeric index. I n principle, the success of this method depends on the extent of the overlap of the distributions corresponding to

Journal

Annals of Human GeneticsWiley

Published: Oct 1, 1969

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