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Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis

Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis We report an atypical case of familial Mediterranean fever (FMF) concomitant with chronic aseptic meningitis. The patient experienced fever, abdominal and back pain because of serositis, and headache because of aseptic meningitis for 4 weeks. Blood examinations revealed increased white blood cells and serum amyloid A level. Medications, including steroids, did not improve his symptoms. However, the patient experienced immediate relief after the administration of colchicine. We diagnosed him as having atypical FMF based on the symptoms, especially positive response to colchicine, and heterozygous mutations on exon2 and 5 (E148Q/S503C) in MEFV gene. Unlike typical FMF, a cause of recurrent aseptic meningitis, atypical FMF might be an underdiagnosed cause of chronic aseptic meningitis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurology and Clinical Neuroscience Wiley

Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis

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References (7)

Publisher
Wiley
Copyright
Copyright © 2018 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd
ISSN
2049-4173
eISSN
2049-4173
DOI
10.1111/ncn3.12232
Publisher site
See Article on Publisher Site

Abstract

We report an atypical case of familial Mediterranean fever (FMF) concomitant with chronic aseptic meningitis. The patient experienced fever, abdominal and back pain because of serositis, and headache because of aseptic meningitis for 4 weeks. Blood examinations revealed increased white blood cells and serum amyloid A level. Medications, including steroids, did not improve his symptoms. However, the patient experienced immediate relief after the administration of colchicine. We diagnosed him as having atypical FMF based on the symptoms, especially positive response to colchicine, and heterozygous mutations on exon2 and 5 (E148Q/S503C) in MEFV gene. Unlike typical FMF, a cause of recurrent aseptic meningitis, atypical FMF might be an underdiagnosed cause of chronic aseptic meningitis.

Journal

Neurology and Clinical NeuroscienceWiley

Published: Nov 1, 2018

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