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Association of prenatal folate status with early childhood wheeze and atopic dermatitis

Association of prenatal folate status with early childhood wheeze and atopic dermatitis INTRODUCTIONWheezing and atopic dermatitis are common and associated with substantial morbidity in early childhood and often precede the onset of asthma later in childhood. Genetics and host factors have been indicated in the complex etiology of atopic diseases, as have environmental and nutritional exposures. High prenatal folic acid exposure has been studied as a risk factor for childhood atopic diseases, due in part to its recognized capacity to epigenetically modify DNA. Some observational studies have suggested that higher folic acid during pregnancy may be associated with increased risk of allergic and respiratory phenotypes in offspring, while other studies found null or inverse associations.Women of childbearing age are advised to consume a daily supplement of 400‐800 μg/d of folic acid to reduce the risk of infants born with neural tube defects. In the USA, mandatory folic acid fortification of many enriched cereal and grain products has been implemented since 1998 to achieve sufficient intake, particularly among women who may have unplanned pregnancies.To date, most studies of prenatal folate exposure and childhood atopic diseases have been conducted in countries without mandatory fortification, and many studies did not capture blood folate levels. Relative to non‐fortified populations, women in the US may experience high http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Association of prenatal folate status with early childhood wheeze and atopic dermatitis

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References (33)

Publisher
Wiley
Copyright
Copyright © 2018 John Wiley & Sons A/S
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/pai.12834
pmid
29168294
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONWheezing and atopic dermatitis are common and associated with substantial morbidity in early childhood and often precede the onset of asthma later in childhood. Genetics and host factors have been indicated in the complex etiology of atopic diseases, as have environmental and nutritional exposures. High prenatal folic acid exposure has been studied as a risk factor for childhood atopic diseases, due in part to its recognized capacity to epigenetically modify DNA. Some observational studies have suggested that higher folic acid during pregnancy may be associated with increased risk of allergic and respiratory phenotypes in offspring, while other studies found null or inverse associations.Women of childbearing age are advised to consume a daily supplement of 400‐800 μg/d of folic acid to reduce the risk of infants born with neural tube defects. In the USA, mandatory folic acid fortification of many enriched cereal and grain products has been implemented since 1998 to achieve sufficient intake, particularly among women who may have unplanned pregnancies.To date, most studies of prenatal folate exposure and childhood atopic diseases have been conducted in countries without mandatory fortification, and many studies did not capture blood folate levels. Relative to non‐fortified populations, women in the US may experience high

Journal

Pediatric Allergy and Immunology – Wiley

Published: Jan 1, 2018

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